Clinical Journal of Gastroenterology

, Volume 7, Issue 2, pp 148–154 | Cite as

Treatment of gastric metastases from renal cell carcinoma with endoscopic therapy

  • Herculano RitaEmail author
  • Alves Isabel
  • Chapim Iolanda
  • Hann Alexander
  • Costa Pedro
  • Carvalho Liliana
  • Monteiro Lucília
  • Santos Sofia
  • Matos Leopoldo
Case Report



Gastric metastases from renal cell carcinoma (RCC) are rare with few cases described in the literature.

Case report

We report the history of a 77-year-old male patient who underwent a right radical nephrectomy because of RCC. Two years after the diagnosis, he presented with abdominal pain and evidence of upper gastrointestinal bleeding. Esophagogastroduodenoscopy revealed a 3 cm, ulcerated, pedunculated polypoid mass in the stomach that was removed with a diathermic snare. Histology with immunohistochemistry confirmed the diagnosis of metastatic RCC. Three months of follow-up revealed no further episode of rebleeding.


We identified (using the PubMed database) 44 cases of gastric metastasis of RCC in the literature; the majority were male patients, with mean age at presentation of 67.2 years and average time from nephrectomy to presentation of gastric metastases of 6.9 years. Our results suggest that endoscopy may have an important role in the treatment of these patients for controlling the complications and/or improving mean survival time.


Gastric metastases of RCC are rare but should be considered even many years after diagnosis and treatment of RCC, particularly in patients with gastrointestinal symptoms.


Renal cell carcinoma Gastric metastases Upper gastrointestinal bleeding Endoscopic treatment 



Conflict of Interest: The authors have nothing to declare.

Human/Animal Rights: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent: Informed consent was obtained from the patient to be included in the study.


  1. 1.
    Campbell SC, Andrew CN. Renal tumours. In: Wein AJ, Kavoussi LR, Novick AC, et al., editors. Campbell-Walsh urology. 9th ed. Saunders Elsevier Pub; 2007. p. 1582–605.Google Scholar
  2. 2.
    Maldazys JD, DeKernion JB. Prognostic factors in metastatic renal cell carcinoma. J Urol. 1986;136:376–9.PubMedGoogle Scholar
  3. 3.
    De Palma GD, Masone S, Rega M, et al. Metastatic tumors of the stomach. Clinical and endoscopic features. World J Gastroenterol. 2006;12:7326–8.PubMedGoogle Scholar
  4. 4.
    Sullivan WG, Cabot EB, Donohue RE. Metastatic renal cell carcinoma to stomach. Urology. 1980;15(4):375–8.PubMedCrossRefGoogle Scholar
  5. 5.
    Nakamura R, Shimada A, Hara Y, et al. One case of intussusception due to intestinal metastasis of renal carcinoma. Jpn J Clin Surg. 1984;43:1637–40.Google Scholar
  6. 6.
    Cosme A, Orive V, Alzate LF, Torrado J, et al. Metástasis gástrica de un hipernefroma. Gastroenterol Hepatol. 1984;7:400–1.Google Scholar
  7. 7.
    Bisesti V, Parrella E, Cataldi C, et al. Ser di un raro caso di metastasi gastrica di adenocarcinoma renale. Osp Ital Pediatr. 1984;19:609–20.Google Scholar
  8. 8.
    Ibáñez Olcoz J, Jiménez López CE, Oteo Revuelta JA, et al. Gastric metastasis of renal adenocarcinoma. Presentation of a case and review of the literature. Rev Esp Enferm Apar Dig. 1989;76:259–61.PubMedGoogle Scholar
  9. 9.
    Márquez JL, Herrera JM, Herrera J, et al. Gastric metastasis of renal cell adenocarcinoma. Rev Esp Enferm Dig. 1992;81:129–30.PubMedGoogle Scholar
  10. 10.
    Durous E, Isaac S, Dubreuil C, et al. Late gastric metastasis of cancer of the kidney. Presse Med. 1992;21:996.PubMedGoogle Scholar
  11. 11.
    Otawa T, Muto I. A case of synchronous gastric metastasis from renal cell carcinoma with the chief complaint of hematemesis. Jpn J Clin Surg. 1992;53:1219–22.Google Scholar
  12. 12.
    Herrera Puerto J, Caballero Gómez M, Márquez Galán JL, et al. Metastatic hypernephroma of the stomach. Arch Esp Urol. 1993;46:729–31.PubMedGoogle Scholar
  13. 13.
    Boruchowicz A, Desreumaux P, Maunoury V, et al. Dysphagia revealing esophageal and gastric metastases of renal carcinoma. Am J Gastroenterol. 1995;90:2263–4.PubMedGoogle Scholar
  14. 14.
    Blake MA, Owens A, O’Donoghue DP, et al. Embolotherapy for massive upper gastrointestinal haemorrhage secondary to metastatic renal cell carcinoma: report of three cases. Gut. 1995;37:835–7.PubMedCentralPubMedCrossRefGoogle Scholar
  15. 15.
    Odori T, Tsuboi Y, Katoh K, et al. A solitary hematogenous metastasis to the gastric wall from renal cell carcinoma four years after radical nephrectomy. J Clin Gastroenterol. 1998;26:153–4.PubMedCrossRefGoogle Scholar
  16. 16.
    Picchio M, Paioletti A, Santini E, Iacoponi S, Cordahi M. Gastric metastasis from renal cell carcinoma fourteen years after radical nephrectomy. Acta Chir Belg. 2000;100:228–30.PubMedGoogle Scholar
  17. 17.
    Mascarenhas B, Konety B, Rubin JT. Recurrent metastatic renal cell carcinoma presenting as a bleeding gastric ulcer after a complete response to high-dose interleukin-2 treatment. Urology. 2001;57:168.PubMedCrossRefGoogle Scholar
  18. 18.
    Kobayashi O, Murakami H, Yoshida T, et al. Clinical diagnosis of metastatic gastric tumors: clinicopathologic findings and prognosis of nine patients in a single cancer center. World J Surg. 2004;28:548–51.PubMedCrossRefGoogle Scholar
  19. 19.
    Kok Wee L, Shyu RY, Sheu LF, Hsieh TY, Yan JC, Chen PJ. Metastatic renal cell cancer. Gastrointest Endosc. 2004;60:265.PubMedCrossRefGoogle Scholar
  20. 20.
    Suárez Fonseca C, Carballido Rodríguez J, González Lama Y, et al. Gastric metastasis from renal cell carcinoma. Pathogenical hypothesis and literature revision. Actas Urol Esp. 2004;28(6):472–6.PubMedCrossRefGoogle Scholar
  21. 21.
    Lamb GW, Moss J, Edwards R, Aitchison M. Case report: octreotide as an adjunct to embolisation in the management of recurrent bleeding upper gastrointestinal metastases from primary renal cell cancer. Int Urol Nephrol. 2005;37:691–3.PubMedCrossRefGoogle Scholar
  22. 22.
    Riviello C, Tanini I, Cipriani G, et al. Unusual gastric and pancreatic metastatic renal cell carcinoma presentation 10 years after surgery and immunotherapy: a case report and a review of literature. World J Gastroenterol. 2006;12:5234–6.PubMedGoogle Scholar
  23. 23.
    Portanova M, Yabar A, Lombardi E, et al. Concomitant gastric and pancreatic metastases from renal cell carcinoma: case study. Rev Gastroenterol Peru. 2006;26:84–8.PubMedGoogle Scholar
  24. 24.
    Pezzoli A, Matarese V, Boccia S, Simone L, et al. Gastrointestinal bleeding from gastric metastasis of renal cell carcinoma, treated by endoscopic polypectomy. Endoscopy. 2007;39(Suppl 1):E52.PubMedCrossRefGoogle Scholar
  25. 25.
    Saidi RF, Remine SG. Isolated gastric metastasis from renal cell carcinoma 10 years after radical nephrectomy. J Gastroenterol Hepatol. 2007;22:143–4.PubMedCrossRefGoogle Scholar
  26. 26.
    Pollheimer MJ, Hinterleitner TA, Pollheimer VS, et al. Renal cell carcinoma metastatic to the stomach: single centre experience and literature review. BJU Int. 2008;102:315–9.PubMedCrossRefGoogle Scholar
  27. 27.
    Ko WO, Yang US, Kim NS, et al. A case of a gastric metastasis of a renal cell carcinoma. Korean J Gastrointest Endosc. 2008;36:288–91.Google Scholar
  28. 28.
    Kibria R, Sharma K, Ali SA, Rao P. Upper gastrointestinal bleeding revealing the stomach metastases of renal cell carcinoma. J Gastrointest Cancer. 2009;40:51–4.PubMedCrossRefGoogle Scholar
  29. 29.
    Yamamoto D, Hamada Y, Okazaki S, et al. Metastatic gastric tumor from renal cell carcinoma. Gastric Cancer. 2009;12:170–3.PubMedCrossRefGoogle Scholar
  30. 30.
    Maeda T, Kozakai N, Nishiyama T, Ishii T, Sugiura H, Nakamura K. Gastric metastasis from renal cell carcinoma 20 months after radical nephrectomy: a case report. Hinyokika Kiyo. 2009;55:137–40.PubMedGoogle Scholar
  31. 31.
    Tiwari P, Tiwari A, Vijay M, et al. Upper gastro-intestinal bleeding—rare presentation of renal cell carcinoma. Urol Ann. 2010;2(3):127–9.PubMedCentralPubMedCrossRefGoogle Scholar
  32. 32.
    García-Campelo R, Quindós M, Vázquez DD, et al. Renal cell carcinoma: complete pathological response in a patient with gastric metastasis of renal cell carcinoma. Anticancer Drugs. 2010;21(Suppl 1):S13–5.PubMedCrossRefGoogle Scholar
  33. 33.
    Sugasawa H, Ichikura T, Ono S, et al. Isolated gastric metastasis from renal cell carcinoma 19 years after radical nephrectomy. Int J Clin Oncol. 2010;15:196–200.PubMedCrossRefGoogle Scholar
  34. 34.
    Eslick GD, Kalantar JS. Gastric metastasis in renal cell carcinoma: a case report and systematic review. J Gastrointest Cancer. 2011;42:296–301.PubMedCrossRefGoogle Scholar
  35. 35.
    Cruz A, Ramírez LM, Sánchez E, et al. Gastric metastasis from renal cancer six years after nephrectomy. Rev Esp Enferm Dig. 2011;103(12):660–1.PubMedCrossRefGoogle Scholar
  36. 36.
    Kim MY, Jung HY, Choi KD, et al. Solitary synchronous metastatic gastric cancer arising from t1b renal cell carcinoma: a case report and systematic review. Gut Liver. 2012;6(3):388–9436.PubMedCentralPubMedCrossRefGoogle Scholar
  37. 37.
    Xu J, Latif S, Wei S. Metastatic renal cell carcinoma presenting as gastric polyps: a case report and review of the literature. Int J Surg Case Rep. 2012;3(12):601–4.PubMedCentralPubMedCrossRefGoogle Scholar
  38. 38.
    Gómez-de-la-Cuesta S, Fernández-Salazar L, Velayos-Jiménez B, et al. Gastric metastasis from renal cell carcinoma. Rev Esp Enferm Dig. 2012;104(6):334–5.PubMedCrossRefGoogle Scholar
  39. 39.
    Siriwardana HP, Harvey MH, Kadirkamanathan SS, et al. Endoscopic mucosal resection of a solitary metastatic tumor in the stomach: a case report. Surg Laparosc Endosc Percutan Tech. 2012;22(3):e132–4.PubMedCrossRefGoogle Scholar
  40. 40.
    Namikawa T, Iwabu J, Kitagawa H, et al. Solitary gastric metastasis from a renal cell carcinoma, presenting 23 years after radical nephrectomy. Endoscopy. 2012;44(Suppl 2 UCTN):E177–8.PubMedGoogle Scholar
  41. 41.
    Rodrigues S, Bastos P, Macedo G. A rare cause of hematemesis: gastric metastases from renal cell carcinoma. Gastrointest Endosc. 2012;75(4):894.PubMedCrossRefGoogle Scholar
  42. 42.
    Thyavihally YB, Mahantshetty U, Chamarajanagar RS, et al. Management of renal cell carcinoma with solitary metastasis. World J Surg Oncol. 2005;3:48.PubMedCentralPubMedCrossRefGoogle Scholar
  43. 43.
    Namikawa T, Munekage M, Kitagawa H, et al. Metastatic gastric tumors arising from renal cell carcinoma: clinical characteristics and outcomes of this uncommon disease. Oncol Lett. 2012;4(4):631–63.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer Japan 2014

Authors and Affiliations

  • Herculano Rita
    • 1
    Email author
  • Alves Isabel
    • 1
  • Chapim Iolanda
    • 1
  • Hann Alexander
    • 2
  • Costa Pedro
    • 1
  • Carvalho Liliana
    • 1
  • Monteiro Lucília
    • 3
  • Santos Sofia
    • 1
  • Matos Leopoldo
    • 1
  1. 1.Department of GastroenterologyEgas Moniz Hospital, Ocidental Lisbon Hospitalar CenterLisbonPortugal
  2. 2.Department of Internal Medicine and GastroenterologyKatharinen HospitalStuttgartGermany
  3. 3.Department of PathologyEgas Moniz Hospital, Ocidental Lisbon Hospitalar CenterLisbonPortugal

Personalised recommendations