Clinical Journal of Gastroenterology

, Volume 6, Issue 6, pp 476–479 | Cite as

Ductal branch-oriented pancreatic resection for an intraductal papillary mucinous neoplasm in the uncinate process that caused recurrent acute pancreatitis: a case report of successful treatment

  • Toshiyuki Natsume
  • Takashi Maruyama
  • Akitoshi Kobayashi
  • Shinichiro Shimizu
  • Hajime Tanaka
  • Hiroshi Matsuzaki
  • Akinari Miyazaki
  • Takumi Ohta
  • Yayoi Sato
  • Yuji Yamamoto
  • Mizuho Aikawa
  • Ryota Otsuka
  • Akitoshi Yanagihara
Case Report

Abstract

Acute pancreatitis reportedly occurs in about 15 % of cases of branch duct (BD)-intraductal papillary mucinous neoplasms (IPMNs), with two-thirds of BD-IPMNs being located in the head or uncinate process of the pancreas. However, the surgical indications and optimal treatment methods for BD-IPMNs have not been established. A 59-year-old Japanese male with epigastralgia was admitted to our hospital. A multidetector row computed tomography (MDCT) scan disclosed grade I acute pancreatitis. Magnetic resonance cholangiopancreatography disclosed a 1.5-cm BD-IPMN in the uncinate process. Two months after discharge, the epigastralgia recurred, and MDCT again revealed grade I pancreatitis. Due to the repeated episodes of pancreatitis, we performed ductal branch-oriented pancreatic resection. To detect the inferior branch of the Wirsung duct and avoid the development of a pancreatic fistula, we injected indigo carmine into the tumor which confirmed ligation of the inferior branch. Histopathologically, the tumor proved to be an adenoma. The postoperative course was uneventful in both the short- and long-term follow-up and, to date, there has been no recurrence of pancreatitis, or diabetes mellitus during the 6 years since pancreatectomy. This procedure is one of the methods that can be used for the successful resection of a BD-IPMN in the uncinate process that caused recurrent acute pancreatitis.

Keywords

Acute pancreatitis IPMN Uncinate process 

Abbreviations

IPMN

Intraductal papillary mucinous neoplasm

MDCT

Multidetector row computed tomography

AP

Acute pancreatitis

PD

Pancreaticoduodenectomy

Notes

Disclosures

Conflict of Interest: The authors declare that they have no conflict of interest.

Human/Animal Rights: All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5)

Informed Consent: Informed consent was obtained from all patients for being included in the study.

References

  1. 1.
    Steinberg W, Tenner S. Acute pancreatitis. N Engl J Med. 1994;330:1198–210.PubMedCrossRefGoogle Scholar
  2. 2.
    McGrath K, Slivka A. Diagnosis and management of intraductal papillary mucinous neoplasia. Nat Clin Pract Gastroenterol Hepatol. 2005;2(316–32):2.Google Scholar
  3. 3.
    Takeuchi K, Tsuzuki Y, Ando T, et al. A case of intraductal papillary-mucinous carcinoma of the pancreas with the onset of acute pancreatitis. Hepatogastroenterology. 2002;49:838–41.PubMedGoogle Scholar
  4. 4.
    Rodriguez JR, Salvia R, Crippa S, et al. Branch-duct intraductal papillary mucinous neoplasms: observations in 145 patients who underwent resection. Gastroenterology. 2007;133:72–9 (quiz 309–310).PubMedCrossRefGoogle Scholar
  5. 5.
    Yamaguchi K, Shimizu S, Yokohata K, et al. Ductal branch-oriented minimal pancreatectomy: two cases of successful treatment. J Hepatobiliary Pancreat Surg. 1999;6(69–7):3.Google Scholar
  6. 6.
    Rosenberger LH, Stein LH, Witkiewicz AK, et al. Intraductal papillary mucinous neoplasm (IPMN) with extra-pancreatic mucin: a case series and review of the literature. J Gastrointest Surg. 2012;16:762–70.PubMedCrossRefGoogle Scholar
  7. 7.
    Hirooka Y, Goto H, Itoh A, et al. Case of intraductal papillary mucinous tumor in which endosonography-guided fine-needle aspiration biopsy caused dissemination. J Gastroenterol Hepatol. 2003;18(1323–132):4.Google Scholar
  8. 8.
    Rotman N, Sastre B, Fagniez PL. Medial pancreatectomy for tumors of the neck of the pancreas. Surgery. 1993;113:532–5.PubMedGoogle Scholar
  9. 9.
    Sperti C, Pasquali C, Ferronato A, et al. Median pancreatectomy for tumors of the neck and body of the pancreas. J Am Coll Surg. 2000;190(711–71):6.Google Scholar
  10. 10.
    Warshaw AL, Rattner DW, Fernandez-del Castillo C, et al. Middle segment pancreatectomy: a novel technique for conserving pancreatic tissue. Arch Surg. 1998;133:327–31.PubMedCrossRefGoogle Scholar
  11. 11.
    Nagai E, Ueki T, Chijiiwa K, et al. Intraductal papillary mucinous neoplasms of the pancreas associated with so-called “mucinous ductal ectasia”. Histochemical and immunohistochemical analysis of 29 cases. Am J Surg Pathol. 1995;19:576–89.PubMedCrossRefGoogle Scholar
  12. 12.
    Paik KY, Choi SH. Experience of limited pancreatic head resection for management of branch duct intraductal papillary mucinous neoplasm in a single center. World J Gastroenterol. 2009;15(2904–290):7.Google Scholar
  13. 13.
    Takada T, Amano H, Ammori BJ. A novel technique for multiple pancreatectomies: removal of unicinate process of the pancreas combined with medial pancreatectomy. J Hepatobiliary Pancreat Surg. 2000;7(49–5):2.Google Scholar
  14. 14.
    Tanaka M, Fernandez-del Castillo C, Adsay V, et al. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12:183–97.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Toshiyuki Natsume
    • 1
  • Takashi Maruyama
    • 1
  • Akitoshi Kobayashi
    • 2
  • Shinichiro Shimizu
    • 3
  • Hajime Tanaka
    • 1
  • Hiroshi Matsuzaki
    • 1
  • Akinari Miyazaki
    • 1
  • Takumi Ohta
    • 1
  • Yayoi Sato
    • 1
  • Yuji Yamamoto
    • 1
  • Mizuho Aikawa
    • 1
  • Ryota Otsuka
    • 1
  • Akitoshi Yanagihara
    • 1
  1. 1.Department of SurgeryFunabashi Municipal Medical CenterFunabashiJapan
  2. 2.Department of Internal MedicineFunabashi Municipal Medical CenterFunabashiJapan
  3. 3.Department of PathologyFunabashi Municipal Medical CenterFunabashiJapan

Personalised recommendations