Effect of infliximab on inflammatory bowel disease with Takayasu arteritis: case series and review of the literature
- 215 Downloads
Takayasu arteritis (TA) and inflammatory bowel disease (IBD) are chronic inflammatory disorders. The mechanisms underlying these diseases are not precisely known, but tumor necrosis factor alpha (TNF-α) is considered to have an important role in the pathophysiology of both TA and IBD. Simultaneous occurrence of both TA and IBD is rare. Our first case was a 42-year-old woman with TA and inflammatory bowel disease unclassified. The patient was refractory to treatment with an immunomodulator, and infliximab (IFX) was started. After starting IFX, clinical remission was achieved and maintained for 2 years. The second case was a 34-year-old woman with TA accompanied by Crohn’s disease. Because her abdominal symptoms relapsed despite treatment with an immunomodulator, IFX was started. Both diseases were well controlled for 2 years by scheduled maintenance therapy with IFX. Relapse of the TA required increased doses of IFX at shorter intervals, which relieved her symptoms. Overall, we identified nine cases for which IFX was effective, including our 2 cases. They may demonstrate the efficacy of IFX for IBD with TA and emphasize the role of TNF-α in the pathophysiology.
KeywordsTakayasu arteritis Inflammatory bowel disease Tumor necrosis factor alpha Infliximab
Conflict of interest
The authors declare that they have no conflict of interest.
- 8.Kellermayer R, Jain AK, Ferry G, Deguzman MM, Guillerman RP. Clinical challenges and images in GI. Aortitis as a rare complication of Crohn’s disease. Gastroenterology. 2008;134(3):668, 898.Google Scholar
- 9.Judah JR, Hammond CJ, Polyak SF, Drane WE, Valentine JF. The coexistence of Crohn’s disease and Takayasu arteritis: diagnosis and treatment of combined disease in three patients. Pract Gastroenterol. 2009;3:50–8.Google Scholar
- 12.Horai Y, Satoru O, Lapalme-Remis S, Sumiyoshi R, Nakashima Y, Suzuki T, et al. Takayasu arteritis developing during treatment of ulcerative colitis with infliximab. Mod Rheumatol. 2012.Google Scholar