Clinical Journal of Gastroenterology

, Volume 6, Issue 2, pp 160–163

Natural interferon-beta plus ribavirin therapy led to sustained virological response after seven unsuccessful courses of anti-viral treatment in a chronic hepatitis C patient

  • Tatsuo Kanda
  • Shingo Nakamoto
  • Makoto Arai
  • Tatsuo Miyamura
  • Shuang Wu
  • Keiichi Fujiwara
  • Osamu Yokosuka
Case Report


We describe a patient infected with hepatitis C virus (HCV) genotype 1 who failed to respond to interferon with or without ribavirin seven times but who then achieved sustained virological response by the combination of interferon-beta plus ribavirin treatment for 48 weeks. He did not respond to stronger treatment such as prolonged peginterferon plus ribavirin treatment for 87 weeks. It might be rare to treat a patient with interferon 8 times considering the cost and time, since patients failing interferon treatment several times are regarded to be refractory to interferon. It is possible that the difference in biological effects between interferon-alfa and interferon-beta might have resulted in a different outcome in our patient. Interferon-beta plus ribavirin therapy might be one of the treatment options for certain patients chronically infected with HCV who do not respond to standard care treatment.


Hepatitis C HCV genotype 1 Interferon-beta Neutralizing antibody Ribavirin Sustained virological response 


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Copyright information

© Springer Japan 2013

Authors and Affiliations

  • Tatsuo Kanda
    • 1
  • Shingo Nakamoto
    • 1
  • Makoto Arai
    • 1
  • Tatsuo Miyamura
    • 1
  • Shuang Wu
    • 1
  • Keiichi Fujiwara
    • 1
  • Osamu Yokosuka
    • 1
  1. 1.Department of Gastroenterology and NephrologyGraduate School of Medicine, Chiba UniversityChibaJapan

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