Clinical Journal of Gastroenterology

, Volume 4, Issue 3, pp 151–156

Successful treatment of ulcerative colitis complicated by Sweet’s syndrome by corticosteroid therapy and leukocytapheresis

  • Tomohiro Terai
  • Mitsushige Sugimoto
  • Satoshi Osawa
  • Ken Sugimoto
  • Takahisa Furuta
  • Shigeru Kanaoka
  • Mutsuhiro Ikuma
Case Report


Ulcerative colitis is occasionally complicated by dermatological disorders presenting as extra-intestinal manifestations, including erythema nodosum and pyoderma gangrenosum. Sweet’s syndrome is considered to be a rare cutaneous disease in patients with ulcerative colitis. To date, only 17 cases of Sweet’s syndrome complicating ulcerative colitis have been reported in the English literature. Here, we report a case of a 41-year-old male who had been suffering from ulcerative colitis for 20 years. He was admitted to hospital with hematochezia, diarrhea and fever, and painful erythematous nodules on the face and arms. Histological examination of skin biopsies showed inflammatory cell infiltration composed mainly of neutrophils without evidence of necrotizing vasculitis, and the condition was diagnosed as Sweet’s syndrome. The patient was treated with prednisolone and leukocytapheresis and the erythematous nodules on the skin, as well as the abdominal symptoms and endoscopic findings of ulcerative colitis, immediately improved. In this paper we report on this case and review the literature concerning ulcerative colitis and Sweet’s syndrome.


Ulcerative colitis Sweet’s syndrome Prednisolone Neutrophilic dermatosis 


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Copyright information

© Springer 2011

Authors and Affiliations

  • Tomohiro Terai
    • 1
  • Mitsushige Sugimoto
    • 1
  • Satoshi Osawa
    • 1
  • Ken Sugimoto
    • 1
  • Takahisa Furuta
    • 2
  • Shigeru Kanaoka
    • 3
  • Mutsuhiro Ikuma
    • 1
  1. 1.First Department of MedicineHamamatsu University School of MedicineShizuokaJapan
  2. 2.Center for Clinical ResearchHamamatsu University School of MedicineShizuokaJapan
  3. 3.Department of Molecular DiagnosisHamamatsu University School of MedicineShizuokaJapan

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