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Advances in Therapy

, Volume 35, Issue 2, pp 153–160 | Cite as

Head and Neck Cancer: A Review of the Impact of Treatment Delay on Outcome

  • Andrés Coca-PelazEmail author
  • Robert P. Takes
  • Kate Hutcheson
  • Nabil F. Saba
  • Missak HaigentzJr.
  • Carol R. Bradford
  • Remco de Bree
  • Primož Strojan
  • Valerie J. Lund
  • William M. Mendenhall
  • Iain J. Nixon
  • Miquel Quer
  • Alessandra Rinaldo
  • Alfio Ferlito
Review

Abstract

Delay between the initial symptoms, diagnosis, and the definitive treatment of head and neck cancers is associated with tumor progression and upstaging. These delays may lead to poor outcomes and may mandate more aggressive treatments with unnecessary morbidity and even mortality. The multidisciplinary team approach for the treatment of patients with head and neck cancers has improved organization of standard clinical guidelines, but this development has yet to translate into a demonstrable impact on survival. We review the association between waiting times (time between diagnosis and initiation of treatment) and clinical outcomes in patients with head and neck squamous cell carcinoma (HNSCC).

Keywords

Head and neck cancer Oncology Prognosis Survival Treatment Waiting time 

Notes

Acknowledgements

This article was written by members of the International Head and Neck Scientific Group (http://www.IHNSG.com).

Funding

No funding or sponsorship was received for this study or publication of this article.

Authorship

All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published.

Disclosures

Andrés Coca-Pelaz, Robert P. Takes, Kate Hutcheson, Nabil F. Saba, Missak Haigentz Jr., Carol R. Bradford, Remco de Bree, Primož Strojan, Valerie J. Lund, William M. Mendenhall, Iain J. Nixon, Miquel Quer, Alessandra Rinaldo, and Alfio Ferlito have nothing to declare.

Compliance with Ethics Guidelines

This article is based on previously conducted and reported studies and does contain studies with human participants performed by some of the authors, but does not contain any studies with animals performed by any of the authors. These previously reported studies are clearly referenced.

Data Availability

Data sharing is not applicable to this article as no datasets were generated or analyzed during the current study.

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Copyright information

© Springer Healthcare Ltd., part of Springer Nature 2018

Authors and Affiliations

  • Andrés Coca-Pelaz
    • 1
    Email author
  • Robert P. Takes
    • 2
  • Kate Hutcheson
    • 3
  • Nabil F. Saba
    • 4
  • Missak HaigentzJr.
    • 5
  • Carol R. Bradford
    • 6
  • Remco de Bree
    • 7
  • Primož Strojan
    • 8
  • Valerie J. Lund
    • 9
  • William M. Mendenhall
    • 10
  • Iain J. Nixon
    • 11
  • Miquel Quer
    • 12
  • Alessandra Rinaldo
    • 13
  • Alfio Ferlito
    • 14
  1. 1.Department of OtolaryngologyHospital Universitario Central de AsturiasOviedoSpain
  2. 2.Department of Otolaryngology-Head and Neck SurgeryRadboud University Medical CenterNijmegenThe Netherlands
  3. 3.Department of Head and Neck Surgery, Section of Speech Pathology and AudiologyMD Anderson Cancer CenterHoustonUSA
  4. 4.Department of Hematology and Medical OncologyThe Winship Cancer Institute of Emory UniversityAtlantaUSA
  5. 5.Division of Hematology/Oncology, Department of MedicineMorristown Medical Center/Atlantic Health SystemMorristownUSA
  6. 6.Department of Otolaryngology-Head and Neck SurgeryUniversity of MichiganAnn ArborUSA
  7. 7.Department of Head and Neck Surgical OncologyUMC Utrecht Cancer Center, University Medical Center UtrechtUtrechtThe Netherlands
  8. 8.Department of Radiation OncologyInstitute of OncologyLjubljanaSlovenia
  9. 9.Professorial Unit, Ear InstituteUniversity College LondonLondonUK
  10. 10.Department of Radiation OncologyUniversity of FloridaGainesvilleUSA
  11. 11.Department of Surgery and Otolaryngology, Head and Neck SurgeryEdinburgh UniversityEdinburghUK
  12. 12.Department of OtolaryngologyHospital Santa Creu i Sant PauBarcelonaSpain
  13. 13.University of Udine School of MedicineUdineItaly
  14. 14.Coordinator of the International Head and Neck Scientific GroupPaduaItaly

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