Advances in Therapy

, Volume 28, Issue 12, pp 1078–1088 | Cite as

A New Ginkgo Fresh Plant Extract Increases Microcirculation and Radical Scavenging Activity in Elderly Patients

  • Andy SuterEmail author
  • Wolfgang Niemer
  • Rainer Klopp
Open Access
Original Research



The authors investigated whether a new ginkgo biloba (ginkgo) fresh plant extract had a positive effect on microcirculation in the skin and liver of elderly individuals, and whether the extract had antioxidative properties in vivo.


In a monocentric, controlled clinical trial with 32 elderly patients, 16 patients received three 90 mg ginkgo extract tablets twice daily for 30 days, and 16 patients acted as untreated controls. On days 0, 10, 20, and 30, microcirculatory parameters were measured using intravital microscopy in combination with reflection spectrometry, and the amount of reduced glutathione in the liver.


This new ginkgo fresh plant extract significantly increased the number of blood cell-perfused nodal points, the venular streaming flow, and the local hematocrit in treated participants compared to control participants and compared to values on day 0. The ginkgo preparation also increased microcirculation in the liver, and possessed antioxidative properties that resulted in significant increases in the amount of the radical scavenger glutathione in treated participants.


The new ginkgo fresh plant extract increased the microcirculation significantly, and at the same time improved the radical scavenging capacity in elderly patients and was very well tolerated. This extract is an interesting adjuvant treatment option for patients suffering from impaired microcirculation and improves mechanisms which inhibit an accelerated expression of atherosclerosis.


clinical trial ginkgo bilob ginkgoaceae glutathione liver microcirculation 


  1. 1.
    Blumenthal M. Herb sales down in mainstream market, up in natural food stores. HerbalGram. 2002;55:60. Available at:http://cms. Last accessed November 9, 2011.Google Scholar
  2. 2.
    European Scientific Cooperative on Phytotherapy. Monographs on the medicinal uses of plant drugs: Ginkgo Folium. Thieme Publishing House, Stuttgart and New York. 2003:136–138.Google Scholar
  3. 3.
    Kubota Y, Tanaka N, Umegaki K, et al. Ginkgo biloba extract-induced relaxation of rat aorta is associated with increase in endothelial intracellular calcium level. Life Sci. 2001;69:2327–2336.PubMedCrossRefGoogle Scholar
  4. 4.
    Wu Y, Li S, Cui W, Zu X, Du J, Wang F. Ginkgo biloba extract improves coronary blood flow in healthy elderly adults: role of endothelium-dependent vasodilation. Phytomedicine. 2008;15:164–169.PubMedCrossRefGoogle Scholar
  5. 5.
    Yoshikawa T, Naito Y, Kondo M. Ginkgo biloba leaf extract: review of biological actions and clinical applications. Antiox Redox Signal. 1999;1:469–480.CrossRefGoogle Scholar
  6. 6.
    Sierpina VS, Wollschlaeger B, Blumenthal M. Ginkgo biloba. Am Fam Physician. 2003;68:923–926.PubMedGoogle Scholar
  7. 7.
    Sun BL, Zhang J, Wang XC, et al. Effects of extract of Ginkgo biloba on spasms of the basilar artery and cerebral microcirculatory perfusion in rats with subarachnoid hemorrhage. Clin Hemorheol Microcirc. 2003;29:231–238.PubMedGoogle Scholar
  8. 8.
    Topp S, Knoefel WT, Schutte A, Brilloff S, Rogiers X, Gundlach M. Ginkgo biloba (EGB 761) improves microcirculation after warm ischemia of the rat liver. Transplant Proc. 2001;33:979–981.PubMedCrossRefGoogle Scholar
  9. 9.
    Zhang C, Zu J, Shi H, Liu J, Qin C. The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats. Am J Chin Med. 2004;32:21–31.PubMedCrossRefGoogle Scholar
  10. 10.
    Költringer P, Langsteger W, Klima G, Reisecker F, Eber O. Hemorheologic effects of ginkgo biloba extract EGb 761. Dose-dependent effect of EGb 761 on microcirculation and viscoelasticity of blood. Fortschr Med. 1993;10:170–172. In German.Google Scholar
  11. 11.
    Massoni G, Piovella C, Fratti L. Effects on microcirculation of Ginkgo-biloba in elderly people. G Gerontol. 1972;20:444–450. In Italian.PubMedGoogle Scholar
  12. 12.
    Jung F, Mrowietz C, Kiesewetter H, Wenzel E. Effect of Ginkgo biloba on fluidity of blood and peripheral microcirculation in volunteers. Arzneimittelforschung. 1990;40:589–593.PubMedGoogle Scholar
  13. 13.
    Mehlsen J, Drabaek H, Wiinberg N, Winther K. Effects of a Ginkgo biloba extract on forearm haemodynamics in healthy volunteers. Clin Physiol Funct Imaging. 2002;22:375–378.PubMedCrossRefGoogle Scholar
  14. 14.
    Wolf S, Suter A, Degenring FH, Jung F, Weber M. Effects of four different Ginkgo biloba extractdoses on retinal blood flow of healthy volunteers. 6th International ESCOP Symposium. Bonn, May 10–11, 2001. Poster.Google Scholar
  15. 15.
    Klopp R. Mikrozirkulation. Im Fokus der Forschung. Einführung in biomechanische, physiologische und pathophysiologische Grundlagen sowie ausgewählte Behandlungsoptionen. Mediquant Verlag AG. Triesen:1. edition, 2008: 580. In German.Google Scholar
  16. 16.
    Klopp R, Schulz J, Niemer W. Effects of the β-receptor blocker nebivolol on the functional state of microcirculation of elderly patients with primary arterialhypertension. Eur J Ger. 2007;9:31–38.Google Scholar
  17. 17.
    Ferguson, GA. Statistical analysis in psychology & education. 3rd ed. New York. 1971;153:219–220.Google Scholar
  18. 18.
    Zhang J, Fu S, Liu S, Mao T, Xiu R. The therapeutic effect of Ginkgo biloba extract in SHR rats and its possible mechanisms based on cerebral microvascular flow and vasomotion. Clin Hemorheol Microcirc. 2000;23:133–138.PubMedGoogle Scholar
  19. 19.
    Siegel G, Schäfer P, Winkler K, Malmsten M. Ginkgo biloba (EGb 761) in arteriosclerosis prophylaxis. Wien Med Wochenschr. 2007;157:288–294.PubMedCrossRefGoogle Scholar
  20. 20.
    Chung KF, Dent G, McCusker M, et al. Effect of a ginkgolide mixture (BN 52063) in antagonizing skin and platelet response to platelet activating factor in man. Lancet. 1987;8527:248–251.CrossRefGoogle Scholar
  21. 21.
    Upton R, editor. American Herbal Pharmacopoeia and Therapeutic Compendium: ginkgo leaf ginkgo leaf dry extract (ginkgo biloba L.) — standards of analysis, quality control, and therapeutics. Santa Cruz (CA). American Herbal Pharmacopoeia. 2003:1–77.Google Scholar
  22. 22.
    Bundesamt für Arzneimittel und Medizinprodukte BfArM. Ginkgo. In: Homöopathisches Arzneibuch HAB. Deutscher Apotheker Verlag; Stuttgart. 2005:1784p.Google Scholar
  23. 23.
    Woelkart K, Feizlmayr E, Dittrich P, et al. Pharmacokinetics of bilobalide, ginkgolide A and B after administration of three different Ginkgo biloba L. preparations in humans. Phytother Res. 2010;24:445–450.PubMedCrossRefGoogle Scholar
  24. 24.
    Bäurle P, Suter A, Wormstall H. Safety and effectiveness of a traditional ginkgo fresh plant extract — results from a clinical trial. Forsch Komplementmed. 2009:16;156–161.PubMedCrossRefGoogle Scholar
  25. 25.
    Perricone C, De Carolis C, Perricone R. Glutathione: a key player in autoimmunity. Autoimmun Rev. 2009;8:697–701.PubMedCrossRefGoogle Scholar
  26. 26.
    Rodríguez M, Ringstad L, Schäfer P, et al. Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patients. Atherosclerosis. 2007;192:438–444.PubMedCrossRefGoogle Scholar
  27. 27.
    Jünger M, Steins A, Hahn M, Häfner HM. Microcirculatory dysfunction in chronic venous insufficiency (CVI). Microcirculation. 2000;7:3–12.CrossRefGoogle Scholar
  28. 28.
    Chierego M, Verdant C, De Backer D. Microcirculatory alterations in critically ill patients. Minerva Anestesiol. 2006;72:199–205.PubMedGoogle Scholar
  29. 29.
    Serné EH, de Jongh RT, Eringa EC, Ijzerman RG, Stehouwer CD. Microvascular dysfunction: a potential pathophysiological role in the metabolic syndrome. Hypertension. 2007;50;204–211.PubMedCrossRefGoogle Scholar
  30. 30.
    Csiki Z, Garai I, Varga J, et al. Microcirculation of the fingers in Raynaud’s syndrome: (99m) Tc-DTPA imaging. Nuklearmedizin. 2005;44:29–32.PubMedGoogle Scholar
  31. 31.
    Belcaro G, Cesarone MR, Nicolaides AN, Vale J, Glass J, Lennox A. Microcirculatory studies in erectile disorders. Curr Med Res Opin. 2000;16:72–75.CrossRefGoogle Scholar
  32. 32.
    Lehr HA. Microcirculatory dysfunction induced by cigarette smoking. Microcirculation. 2000;7:367–384.PubMedGoogle Scholar
  33. 33.
    Ding J, Patton N, Deary IJ, et al. Retinal microvascular abnormalities and cognitive dysfunction: a systematic review. Br J Ophthalmol. 2008;92:1017–1025.PubMedCrossRefGoogle Scholar
  34. 34.
    James MA, Tullett J, Hemsley AG, Shore AC. Effects of aging and hypertension on the microcirculation. Hypertension. 2006;47:968–974.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Healthcare 2011

Authors and Affiliations

  1. 1.A. Vogel Bioforce AGRoggwilSwitzerland
  2. 2.Institute for MicrocirculationBerlinGermany

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