Advances in Therapy

, Volume 28, Supplement 8, pp 14–19

Prolonged treatment with lenalidomide in relapsed and refractory multiple myeloma

  • Carlos Aguilar Franco
  • Luis Palomera
  • Jose Joaquín Ruiz Arredondo
  • Jesús Martín Sánchez
Clinical Cases

DOI: 10.1007/s12325-011-0081-6

Cite this article as:
Franco, C.A., Palomera, L., Arredondo, J.J.R. et al. Adv Therapy (2011) 28(Suppl 8): 14. doi:10.1007/s12325-011-0081-6


The medical treatment of multiple myeloma has significantly improved over the last few years. Lenalidomide is an immunomodulatory agent approved, in combination with dexamethasone, to treat this disease. The agent is well tolerated and results in disease improvement in 60% of treated patients. The overall outcome of patients who achieve a response is better than those who do not. However, attaining a response can take several months. Prolonged treatment has been associated with induction of responses of better quality and maintenance of responses, leading to better long-term outcomes. The clinical cases presented here illustrate how continued long-term administration of lenalidomide in combination with dexamethasone: 1) is effective for patients who are resistant to thalidomide, regardless of the type of prior therapy; 2) is suitable for patients with neuropathy and renal impairment: and finally 3) leads to a long lasting, clinically meaningful outcome when treatment is adapted to the best tolerated dose.


continued long-term administration dexamethasone lenalidomide multiple myeloma thalidomide-resistant 

Copyright information

© Springer Healthcare 2011

Authors and Affiliations

  • Carlos Aguilar Franco
    • 1
  • Luis Palomera
    • 2
  • Jose Joaquín Ruiz Arredondo
    • 3
  • Jesús Martín Sánchez
    • 4
  1. 1.Hematology DepartmentHospital General Santa BárbaraSoriaSpain
  2. 2.Hematology DepartmentHospital Clínico Universitario Lozano BlesaZaragozaSpain
  3. 3.Hematology Department, Hospital de AntequeraASNMAntequera, MálagaSpain
  4. 4.Department of HematologyHospital Universitario Virgen del Rocío, SevillaSevillaSpain

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