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Advances in Therapy

, Volume 28, Issue 4, pp 334–340 | Cite as

AVAglio: Phase 3 trial of bevacizumab plus temozolomide and radiotherapy in newly diagnosed glioblastoma multiforme

  • O. L. Chinot
  • T. de La Motte Rouge
  • N. Moore
  • A. Zeaiter
  • A. Das
  • H. Phillips
  • Z. Modrusan
  • T. Cloughesy
Open Access
Review

Abstract

Despite treatment with the current standard-of-care therapies, patients with newly diagnosed glioblastoma multiforme (GBM) exhibit dismal prognoses. Bevacizumab has demonstrated activity in patients with recurrent GBM and phase 2 trials indicate that the combination of bevacizumab with standard-of-care therapy is feasible and active for patients with newly diagnosed GBM. Bevacizumab has been granted US approval for use as single-agent therapy for patients with progressive GBM following prior therapy, although it has not received approval for use in patients with GBM in Europe. Phase 3 studies have been initiated in patients with newly diagnosed GBM and are currently recruiting patients. We describe the protocol for the AVAglio phase 3 registration trial, which is designed to evaluate the efficacy and safety of combining bevacizumab with standard-of-care therapy in patients with newly diagnosed GBM.

Keywords

bevacizumab clinical trial glioblastoma multiforme phase 3 

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Copyright information

© Springer Healthcare 2011

Authors and Affiliations

  • O. L. Chinot
    • 1
  • T. de La Motte Rouge
    • 2
  • N. Moore
    • 3
  • A. Zeaiter
    • 3
  • A. Das
    • 4
  • H. Phillips
    • 4
  • Z. Modrusan
    • 4
  • T. Cloughesy
    • 5
  1. 1.Service de Neuro-Oncologie, Centre Hospitalo-Universitaire TimoneUniversité de la MéditerranéeMarseilles Cedex 05France
  2. 2.Service d’Oncologie MédicaleGroupe Hospitalier Pitié SalpétrièreParisFrance
  3. 3.F. Hoffmann-La Roche Ltd.BaselSwitzerland
  4. 4.Genentech, Inc.San FranciscoUSA
  5. 5.David Geffen School of MedicineUniversity of CaliforniaLos AngelesUSA

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