Advances in Therapy

, Volume 27, Issue 10, pp 704–713

Current immunochemotherapy strategies in follicular lymphoma

  • Eva Giné
  • Gonzalo Gutiérrez-García
  • Armando López-Guillermo
Review

DOI: 10.1007/s12325-010-0069-7

Cite this article as:
Giné, E., Gutiérrez-García, G. & López-Guillermo, A. Adv Therapy (2010) 27: 704. doi:10.1007/s12325-010-0069-7

Abstract

Nowadays, there is no consensus about the best treatment for patients with follicular lymphoma (FL) in differing situations. In frontline treatment, a watchful waiting policy remains a good option if the patient has no risk criteria; the role of rituximab is under investigation in this setting. In patients needing therapy, immunotherapy or immunochemotherapy are the best options; although it has not been established which chemotherapy, including cyclophosphamide, vincristine, and prednisone (CVP); cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP); fludarabine, or bendamustine combinations, is the best partner for rituximab. Following frontline treatment, recent and still unpublished data strongly suggest a role for maintenance with rituximab, instead of observation only. At relapse, immunochemotherapy is the standard induction approach. The role of maintenance after induction is well established, although comparative studies with autologous stem-cell transplantation (ASCT) or other combinations are warranted. The role of ASCT in this setting is a matter of discussion. Other monoclonal antibodies, as well as vaccines and other immunotherapies, are currently under investigation. Finally, allogeneic transplantation should be reserved for a very select group of young high-risk patients in the setting of clinical trials.

Keywords

follicular lymphoma immunochemotherapy strategies rituximab 

Copyright information

© Springer Healthcare 2010

Authors and Affiliations

  • Eva Giné
    • 1
  • Gonzalo Gutiérrez-García
    • 1
  • Armando López-Guillermo
    • 1
  1. 1.Department of HematologyHospital ClinicBarcelonaSpain

Personalised recommendations