Advances in Therapy

, Volume 26, Issue 11, pp 999–1011 | Cite as

Prasugrel: Clinical development and therapeutic application

  • Daniel R. GuerraEmail author
  • James E. Tcheng


Dual antiplatelet therapy with aspirin and clopidogrel is a cornerstone of the management of patients with acute coronary syndromes and following percutaneous coronary intervention. Despite the proven benefits, clear limitations of clopidogrel exist. Prasugrel is a third-generation thienopyridine antiplatelet agent with pharmacologic characteristics that overcome some of the limitations of clopidogrel, but at the expense of increased bleeding. The promising results seen with prasugrel in large, randomized trials led to its recent approval by the US Food and Drug Administration for reducing thrombotic cardiovascular events in patients with acute coronary syndromes managed with percutaneous coronary intervention. This article will review the limitations of standard antiplatelet therapy and discuss the clinical application of prasugrel.


acute coronary syndrome clopidogrel percutaneous coronary intervention prasugrel 


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Copyright information

© Springer Healthcare Communications 2009

Authors and Affiliations

  1. 1.Cardiac Study CenterTacomaUSA
  2. 2.Division of Cardiovascular MedicineDuke University Medical CenterDurhamUSA

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