Forum

, Volume 29, Issue 4, pp 300–304

Neue Substanzen für die Therapie solider Tumoren

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Zusammenfassung

In den letzten Jahren konnten die systemtherapeutischen Optionen solider Tumoren weiterführend deutlich verbessert werden. Neben verschiedenen neuen und teilweise auch neuartigen („first in class“) molekular zielgerichteten Substanzen, z. B. Hedgehog-Signalweg-Inhibitoren und Inhibitoren der mitogenaktivierten extrazellulär regulierten Kinase (MEK) oder Fusionsproteine, wurden auch einige neue klassische zytotoxische Substanzen zugelassen bzw. zur Zulassung eingereicht. Allerdings sind nur einige wenige zytotoxische Substanzen gegenüber einer Vielzahl an molekular zielgerichteten Substanzen neu dazugekommen. Mittlerweile sind auch die ersten Konjugate aus Rezeptorantikörpern oder -liganden und zytotoxischen Substanzen für solide Tumoren verfügbar (Mammakarzinom und in Kürze Ovarialkarzinom). Besonders vielversprechend sind die Weiterentwicklung der seit einigen Jahren beim malignen Melanom eingesetzten immunmodulatorischen Therapie und deren Ausweitung auf neue Substanzen und Kombinationen sowie weitere Indikationsgebiete.

Schlüsselwörter

Krebsmedikamente Medizinische Onkologie Molekular zielgerichtete Therapie Zytotoxische Substanzen Immunmodulatorische Therapie 

New agents for treatment of solid tumors

Abstract

Systemic treatment options for solid tumors have steadily improved during recent years. Besides several new and sometimes novel first in class molecular targeting agents, e.g. hedgehog and mitogen-activated or extracellular signal-regulated protein kinase (MEK) inhibitors or fusion proteins, some classical cytotoxic agents were licensed or submitted for approval. However, only very few cytotoxic agents have become available compared to a large number of molecular targeting agents. Interestingly, conjugates containing receptor antibodies or ligands and cytotoxic agents are now available for solid tumors (i.e. breast cancer and ovarian cancer soon to follow). Further development of immunomodulatory treatment which has already been used for malignant melanoma for several years, seems to be particularly promising with respect to evaluating new agents or combinations and extending the use towards other malignant diseases.

Keywords

Anticancer agents Medical oncology Molecular targeted therapy Cytotoxic agents Immunomodulatory therapy 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.II. Medizinische Klinik und Poliklinik, Hubertus Wald Tumorzentrum, Universitäres Cancer Center HamburgUniversitätsklinikum Hamburg-EppendorfHamburgDeutschland

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