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, Volume 29, Issue 2, pp 112–118 | Cite as

Monoklonale Antikörper in der Onkologie

Immuntherapien
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Zusammenfassung

Die Behandlung mit monoklonalen Antikörpern stellt eine zentrale Säule in der modernen Krebstherapie dar. In Deutschland sind derzeit 11 unkonjugierte Antikörper (Catumaxomab, Rituximab, Cetuximab, Bevacizumab, Eculizumab, Alemtuzumab, Trastuzumab, Pertuzumab, Ofatumumab, Panitumumab und Ipilimumab) sowie 2 konjugierte monoklonale Antikörper (90Yttrium-Ibritumomab-Tiuxetan und Brentuximab Vedotin) zur antitumoralen Immuntherapie zugelassen. Eine bemerkenswerte Entwicklung in der spezifischen Antitumorimmuntherapie stellen immunmodulatorische (Checkpoint-)Antikörper dar, wie z. B. Anti-CTLA-4- und Anti-PD-1- bzw. Anti-PD-L1-Antikörper, die vielversprechende klinische Erfolge verzeichnen.

Schlüsselwörter

Hämatologische Erkrankungen Tumoren Monoklonale Antikörper Krebstherapie Immunmodulation 

Monoclonal antibodies in oncology

Immunotherapies

Abstract

In current treatment strategies for patients with hematological malignancies and solid tumors, monoclonal antibody therapy has evolved into one of the most successful and most important therapeutic concepts. To date 11 unconjugated monoclonal antibodies (catumaxomab, rituximab, cetuximab, bevacizumab, eculizumab, alemtuzumab, trastuzumab, pertuzumab, ofatumumab, panitumumab and ipilimumab) and 2 conjugated monoclonal antibodies (90Yttrium-ibritumomab tiuxetan and brentuximab vedontin) are currently approved for anti-tumor immunotherapy in Germany. The remarkable development of immunomodulatory (checkpoint) antibodies, such as anti-CTLA-4, anti-PD1 and anti-PD-LA has recently achieved very promising clinical success.

Keywords

Hematologic malignancies Neoplasms Monoclonal antibodies Cancer treatment Immunomodulation 

Notes

Einhaltung ethischer Richtlinien

Interessenkonflikt. J. Nolting, D. Wolf und B. Brossart geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Medizinische Klinik III für Hämatologie, Onkologie und RheumatologieUniversitätsklinikum BonnBonnDeutschland

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