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Functional Convergence of Motor and Social Processes in Lobule IV/V of the Mouse Cerebellum

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Abstract

Topographic organization of the cerebellum is largely segregated into the anterior and posterior lobes that represent its “motor” and “non-motor” functions, respectively. Although patients with damage to the anterior cerebellum often exhibit motor deficits, it remains unclear whether and how such an injury affects cognitive and social behaviors. To address this, we perturbed the activity of major anterior lobule IV/V in mice by either neurotoxic lesion or chemogenetic excitation of Purkinje cells in the cerebellar cortex. We found that both of the manipulations impaired motor coordination, but not general locomotion or anxiety-related behavior. The lesioned animals showed memory deficits in object recognition and social-associative recognition tests, which were confounded by a lack of exploration. Chemogenetic excitation of Purkinje cells disrupted the animals’ social approach in a less-preferred context and social memory, without affecting their overall exploration and object-based memory. In a free social interaction test, the two groups exhibited less interaction with a stranger conspecific. Subsequent c-Fos imaging indicated that decreased neuronal activities in the medial prefrontal cortex, hippocampal dentate gyrus, parahippocampal cortices, and basolateral amygdala, as well as disorganized modular structures of the brain networks might underlie the reduced social interaction. These findings suggest that the anterior cerebellum plays an intricate role in processing motor, cognitive, and social functions.

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Acknowledgements

AAV8-Pcp2-hM3Dq-mCherry was generated by Dr. Ezequiel Marron Fernandez de Velasco in the University of Minnesota Viral Vector and Cloning Core with a plasmid from Addgene (a gift from Dr. Bryan Roth). AAV5-hSyn-EGFP was purchased from Addgene (a gift from Dr. Bryan Roth). We thank Dr. Matthew Slattery in our department for his invaluable inputs.

Funding

This study was supported by the National Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) grant R15NS112964 to YMY, the Winston and Maxine Wallin Neuroscience Discovery Fund to YMY, and the University of Minnesota faculty start-up fund to YMY. We also appreciate the funding support from the DFG to JPH (HU 306/27-3).

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Authors and Affiliations

  1. Department of Biomedical Sciences, University of Minnesota Medical School, 1035 University Drive, Duluth, MN, 55812, USA

    Owen Y. Chao, Hao Zhang, Salil Saurav Pathak & Yi-Mei Yang

  2. Center for Behavioral Neuroscience, Heinrich Heine University of Düsseldorf, Düsseldorf, Germany

    Joseph P. Huston

  3. Department of Neuroscience, University of Minnesota, Minneapolis, MN, 55455, USA

    Yi-Mei Yang

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  1. Owen Y. Chao
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Contributions

OYC and YMY designed the project, performed the experiments, and analyzed the data. HZ and SSP contributed to data analysis and colony maintenance. JPH provided critical inputs and technical consultations. OYC, YMY, and JPH wrote the manuscript.

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Correspondence to Yi-Mei Yang.

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Chao, O.Y., Zhang, H., Pathak, S.S. et al. Functional Convergence of Motor and Social Processes in Lobule IV/V of the Mouse Cerebellum. Cerebellum 20, 836–852 (2021). https://doi.org/10.1007/s12311-021-01246-7

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