Vestibular Hyperreflexia and Opsoclonus in Acute Hepatitis A Virus Infection
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Opsoclonus refers to a burst of involuntary, arrhythmic, to-and-fro saccadic oscillations in multiple planes without an intersaccadic pause [1, 2]. Opsoclonus usually results from autoimmunity from preceding infections or dormant neoplasm [3, 4]. Opsoclonus often presents with other neurological symptoms and signs such as dizziness, myoclonus, ataxia, and mental confusion [3, 4]. In this study, we report vestibular hyperreflexia in a patient with opsoclonus-myoclonus syndrome as a rare complication of acute hepatitis A virus (HAV) infection.
This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT (NRF-2017R1C1B1008582).
Dr. S.U. Lee analyzed and interpreted the data and wrote the manuscript. Drs. H.J. Kim, J. Lee, H.J. Oh, and J.S. Kim analyzed and interpreted the data and revised the manuscript. Dr. J.Y. Choi designed and conceptualized the study, interpreted the data, and revised the manuscript.
Compliance with Ethical Standards
Conflict of Interest
Dr. J.S. Kim serves as an associate editor of Frontiers in Neuro-otology and on the editorial boards of the Journal of Korean Society of Clinical Neurophysiology, the Journal of Clinical Neurology, Frontiers in Neuro-ophthalmology, the Journal of Neuro-ophthalmology, the Journal of Vestibular Research, the Journal of Neurology, and Medicine. Others have no conflicts of interest to disclose.
This study followed the tenets of the Declaration of Helsinki and was performed according to the guidelines of the Institutional Review Board of Seoul National University Bundang Hospital (B-1802-448-704).