Ocular Motor System Control Models and the Cerebellum: Hypothetical Mechanisms
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To review our studies and “top-down” models of saccadic intrusions and infantile nystagmus syndrome with the aim of hypothesizing areas of cerebellar connections controlling parts of the ocular motor subsystems involved in both types of function and dysfunction. The methods of eye-movement recording and modeling are described in detail in the cited references. Saccadic intrusions, such as square-wave jerks and square-wave oscillations, can be simulated by a single malfunction, whereas staircase saccadic intrusions required two independent malfunctions. The major infantile nystagmus syndrome waveforms are traceable to a failure to calibrate the damping ratio of the smooth pursuit system. The use of a behavioral ocular motor system model demonstrated how putative cerebellar dysfunctions could accurately simulate both the oscillations and the ocular motor responses seen in patients with both saccadic and pursuit disorders.
KeywordsOcular motor system Cerebellum Saccadic intrusions/oscillations Nystagmus
Compliance with Ethical Standards
Conflicts of Interest
The authors declare that there is no conflict of interest.
- 1.Robinson DA. How the oculomotor system repairs itself. Investig Ophthalmol. 1975;14:413.Google Scholar
- 2.Young LR, Stark L. A discrete model for eye tracking movements. IEEE Trans Military Elect MIL. 1963;7:13–115.Google Scholar
- 6.Dell’osso LF. A dual-mode model for the normal eye tracking system and the system with nystagmus (PhD dissertation). Laramie: University of Wyoming; 1968. p. 1–131.Google Scholar
- 7.CEMAS_Working_Group. A National Eye Institute sponsored workshop and publication on the Classification of Eye Movement Abnormalities and Strabismus (CEMAS). In The National Eye Institute publications. 2001. nei.nih.gov-sites-default-files-nei-pdfs-cemas. Accessed 30 Dec 2018.
- 24.Dell'Osso LF. Nystagmus therapies: types, sites, and measures. OMLAB Report. 2005;111905:1–4.Google Scholar
- 25.Dell'Osso LF. Original ocular motor analysis of the first human with achiasma: documentation of work done in 1994. OMLAB Report. 2006;090506:1–21.Google Scholar
- 26.Dell’Osso LF, Wang Z, Leigh RJ, Jacobs JB. Hypothetical explanation for the role of proprioception in the damping of infantile nystagmus by tenotomy surgery: the small-signal gain hypothesis. In: Callaos N, editors. Proceedings of the WMSCI 2006 Conference. Orlando, FL; 2006. pp. 39–44.Google Scholar
- 28.Dell'Osso LF, Jacobs JB. Normal pursiut-system limitations—first discovered in infantile nystagmus syndrome. J Eye Mov Res. 2013;6:1–24.Google Scholar
- 31.Wang ZI, Dell'Osso LF. A unifying model-based hypothesis for the diverse waveforms of infantile nystagmus syndrome. J Eye Mov Res. 2011;4:1–18.Google Scholar
- 32.Dell'Osso LF. A hypothetical fixation system capable of extending foveation in congenital nystagmus. J Neuroophthalmol. 2002;22:185–6.Google Scholar
- 35.Leigh RJ, Zee DS. The neurology of eye movements. In: Contemporary neurology series. edition 3 ed. New York: Oxford University Press; 1999.Google Scholar