The Cerebellum

, Volume 12, Issue 5, pp 617–622 | Cite as

Tractography Demonstrates Dentate-rubro-thalamic Tract Disruption in an Adult with Cerebellar Mutism

  • Kirsten van BaarsenEmail author
  • Michiel Kleinnijenhuis
  • Tom Konert
  • Anne-Marie van Cappellen van Walsum
  • André Grotenhuis
Original Paper


A 55-year-old female is presented with transient cerebellar mutism caused by a well-circumscribed left pontine infarction due to postoperative basilar perforator occlusion. Although conventional T2 imaging shows a well-demarcated lesion confined to the pontine region, diffusion tensor imaging shows an asymmetry in fractional anisotropy in the superior cerebellar peduncle. This supports the general hypothesis that cerebellar mutism is caused by functional disruption of the dentate-rubro-thalamic tract. Correlating postoperative anatomic changes to a heterogenic clinical syndrome remains challenging, however.


Cerebellar mutism Posterior fossa syndrome (PFS) Superior cerebellar peduncle (SCP) Dentate-rubro-thalamic (DRT) tract Pons Tractography 



We would like to thank Dr. F.J. Meyer, radiologist of the Radboud University Nijmegen Medical Centre, for providing conventional MR images.

Conflict of Interest

The authors declare that there is no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Kirsten van Baarsen
    • 1
    Email author
  • Michiel Kleinnijenhuis
    • 2
    • 3
  • Tom Konert
    • 1
    • 2
  • Anne-Marie van Cappellen van Walsum
    • 2
    • 3
    • 4
  • André Grotenhuis
    • 1
  1. 1.Department of NeurosurgeryRadboud University Nijmegen Medical CentreNijmegenThe Netherlands
  2. 2.Department of AnatomyRadboud University Nijmegen Medical CentreNijmegenThe Netherlands
  3. 3.Radboud University NijmegenDonders Institute for Brain, Cognition and BehaviourNijmegenThe Netherlands
  4. 4.MIRA Institute for Biomedical Technology and Technical MedicineUniversity of TwenteEnschedeThe Netherlands

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