Tractography Demonstrates Dentate-rubro-thalamic Tract Disruption in an Adult with Cerebellar Mutism
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A 55-year-old female is presented with transient cerebellar mutism caused by a well-circumscribed left pontine infarction due to postoperative basilar perforator occlusion. Although conventional T2 imaging shows a well-demarcated lesion confined to the pontine region, diffusion tensor imaging shows an asymmetry in fractional anisotropy in the superior cerebellar peduncle. This supports the general hypothesis that cerebellar mutism is caused by functional disruption of the dentate-rubro-thalamic tract. Correlating postoperative anatomic changes to a heterogenic clinical syndrome remains challenging, however.
KeywordsCerebellar mutism Posterior fossa syndrome (PFS) Superior cerebellar peduncle (SCP) Dentate-rubro-thalamic (DRT) tract Pons Tractography
We would like to thank Dr. F.J. Meyer, radiologist of the Radboud University Nijmegen Medical Centre, for providing conventional MR images.
Conflict of Interest
The authors declare that there is no conflict of interest.
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