The Cerebellum

, Volume 12, Issue 3, pp 294–296 | Cite as

Hypothalamic Histaminergic and Orexinergic Modulation on Cerebellar and Vestibular Motor Control

Original Paper


Somatic–nonsomatic integration is critical for generation and execution of an appropriate and coordinated behavioral response to changes in internal and external environments. However, the underlying neural substrates and mechanisms are still enigmatic. Intriguingly, the central histaminergic and orexinergic systems originating from the hypothalamus, a high autonomic regulatory center, innervate almost the whole brain including various subcortical motor structures, particularly the cerebellum and vestibular nuclei. Here, we suggest that the hypothalamic histaminergic and orexinergic system bridging the nonsomatic center to somatic motor structures may actively modulate the cerebellar and vestibular nuclear neurons and subsequently participate in motor control and somatic–nonsomatic integration.


Histamine Orexin Hypothalamus Cerebellum Vestibular nuclei Motor control 



The works were supported by grants 31070959, 31071021, 31171050, and NSFC/RGC Joint Research Scheme 30931160433 from the National Natural Science Foundation of China; RFDP grant 20100091110016, NCET Program, and Fundamental Research Fund for the Central Universities 1095020821 from the State Educational Ministry of China; grant BK2011014 from the Natural Science Foundation of Jiangsu Province, China.


  1. 1.
    Zhu JN, Yung WH, Kwok-Chong Chow B, Chan YS, Wang JJ. The cerebellar-hypothalamic circuits: potential pathways underlying cerebellar involvement in somatic–visceral integration. Brain Res Rev. 2006;52(1):93–106.PubMedCrossRefGoogle Scholar
  2. 2.
    Zhu JN, Wang JJ. The cerebellum in feeding control: possible function and mechanism. Cell Mol Neurobiol. 2008;28(4):469–78.PubMedCrossRefGoogle Scholar
  3. 3.
    Haines DE, Dietrichs E, Mihailoff GA, McDonald EF. The cerebellar–hypothalamic axis: basic circuits and clinical observations. Int Rev Neurobiol. 1997;41:83–107.PubMedCrossRefGoogle Scholar
  4. 4.
    Dietrichs E. Cerebellar autonomic function: direct hypothalamocerebellar pathway. Science. 1984;223(4636):591–3.PubMedCrossRefGoogle Scholar
  5. 5.
    Li B, Guo CL, Tang J, Zhu JN, Wang JJ. Cerebellar fastigial nuclear inputs and peripheral feeding signals converge on neurons in the dorsomedial hypothalamic nucleus. Neurosignals. 2009;17(2):132–43.PubMedCrossRefGoogle Scholar
  6. 6.
    Song YN, Li HZ, Zhu JN, Guo CL, Wang JJ. Histamine improves rat rota-rod and balance beam performances through H2 receptors in the cerebellar interpositus nucleus. Neuroscience. 2006;140(1):33–43.PubMedCrossRefGoogle Scholar
  7. 7.
    He YC, Wu GY, Li D, Tang B, Li B, Ding Y, et al. Histamine promotes rat motor performances by activation of H2 receptors in the cerebellar fastigial nucleus. Behav Brain Res. 2012;228(1):44–52.PubMedCrossRefGoogle Scholar
  8. 8.
    Yu L, Zhang XY, Zhang J, Zhu JN, Wang JJ. Orexins excite neurons of the rat cerebellar nucleus interpositus via orexin 2 receptors in vitro. Cerebellum. 2010;9(1):88–95.PubMedCrossRefGoogle Scholar
  9. 9.
    Haas HL, Sergeeva OA, Selbach O. Histamine in the nervous system. Physiol Rev. 2008;88(3):1183–241.PubMedCrossRefGoogle Scholar
  10. 10.
    Sakurai T. The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat Rev Neurosci. 2007;8(3):171–81.PubMedCrossRefGoogle Scholar
  11. 11.
    Wang JJ, Dutia MB. Effects of histamine and betahistine on rat medial vestibular nucleus neurones: possible mechanism of action of anti-histaminergic drugs in vertigo and motion sickness. Exp Brain Res. 1995;105(1):18–24.PubMedCrossRefGoogle Scholar
  12. 12.
    Zhang J, Han XH, Li HZ, Zhu JN, Wang JJ. Histamine excites rat lateral vestibular nuclear neurons through activation of post-synaptic H2 receptors. Neurosci Lett. 2008;448(1):15–9.PubMedCrossRefGoogle Scholar
  13. 13.
    Zhuang QX, Wu YH, Wu GY, Zhu JN, Wang JJ. Histamine excites rat superior vestibular nuclear neurons via postsynaptic H1 and H2 receptors in vitro. NeuroSignals. 2012. doi: 10.1159/000341980.
  14. 14.
    Wu GY, Han XH, Zhuang QX, Zhang J, Yung WH, Chan YS, et al. Excitatory effect of histamine on rat spinal motoneurons by activation of both H1 and H2 receptors in vitro. J Neurosci Res. 2012;90(1):132–42.PubMedCrossRefGoogle Scholar
  15. 15.
    Zhang J, Li B, Yu L, He YC, Li HZ, Zhu JN, et al. A role for orexin in central vestibular motor control. Neuron. 2011;69(4):793–804.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Department of Biological Science and Technology and State Key Laboratory of Pharmaceutical Biotechnology, School of Life SciencesNanjing UniversityNanjingChina

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