Cerebellar Syndrome in Chronic Cyclic Magnesium Depletion
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To the Editor:
Combination of intermittent cerebellar ataxia, nystagmus, and generalized convulsions associated with isolated hypomagnesaemia has been rarely reported . I described a patient with recurrent episodes of weakness, cognitive impairment, transient hemisensory loss, and restless legs syndrome secondary to chronic magnesium depletion . The sister of the patient we evaluated is also affected by magnesium depletion and this fact supports the theory that the condition may be the result of a genetic disorder. She was referred to our unit because of gait impairment and falls. The patient, a 61-year-old woman, had past history of obesity, high blood pressure, type 2 diabetes mellitus, and obstructive sleep apnea (OSA). Ten years before the admission, the patient had begun experiencing weakness and paresthesia in the legs, gait disturbance, and multiple falls. Complete investigations including MRI, electroencephalography, and electromyography only showed bitemporal...
KeywordsObstructive Sleep Apnea Enoxaparin Oxcarbazepine Eclampsia Posterior Reversible Encephalopathy Syndrome
I would like to thank to Dr. RP Lifton and Dr. UI Scholl for the genetic study performed at the Departments of Genetics and Internal Medicine and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA.
Conflicts of Interest
The author declares that he does not have relationships with companies relevant to the letter. The author did not receive funding or support from any source.