The Cerebellum

, Volume 9, Issue 4, pp 603–605 | Cite as

Depressive Mood is Associated with Ataxic and Non-Ataxic Neurological Dysfunction in SCA3 Patients

  • Jonas Alex Morales SauteEmail author
  • Andrew Chaves Feitosa da Silva
  • Karina Carvalho Donis
  • Leonardo Vedolin
  • Maria Luiza Saraiva-Pereira
  • Laura Bannach Jardim
Letter to the Editor

We read with interest the article recently published in Cerebellum by Klinke et al., entitled “Neuropsychological features of patients with spinocerebellar ataxia (SCA) types 1, 2, 3, and 6,” particularly because it pertains to the depressive mood scores obtained in those patients [1]. SCAs are a group of autosomal dominant ataxic disorders affecting mainly the cerebellum and its afferent and efferent connections; however, in most SCAs the consecutive degenerative process also involves extracerebellar structures [2].

A recent survey of subjective health status performed in 526 SCA patients from the European Integrated Project on Spinocerebellar Ataxias (EUROSCA) clinical group, found that 46% of those patients reported depression/anxiety problems, which was one of the three independent predictors of subjective health status together with ataxia severity and extent of noncerebellar involvement [3]. We previously reported that SCA3 symptomatic patients have higher depressive mood scores...


Depressive Symptom Beck Depression Inventory Spinocerebellar Ataxia Beck Depression Inventory Score SCA3 Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This research was supported by the Brazilian funding agencies FIPE-HCPA, CNPq, INAGEMP and FAPERGS.

Financial Disclosure

None of the authors declared a conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jonas Alex Morales Saute
    • 1
    • 2
    Email author
  • Andrew Chaves Feitosa da Silva
    • 3
  • Karina Carvalho Donis
    • 3
  • Leonardo Vedolin
    • 4
  • Maria Luiza Saraiva-Pereira
    • 3
  • Laura Bannach Jardim
    • 1
    • 3
    • 5
  1. 1.Postgraduate Program in Medical SciencesUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Neurology ServiceHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  3. 3.Medical Genetics ServiceHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  4. 4.Neuroradiology ServiceHospital Moinhos de VentoPorto AlegreBrazil
  5. 5.Department of Internal MedicineUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

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