Advertisement

The Cerebellum

, Volume 9, Issue 4, pp 603–605 | Cite as

Depressive Mood is Associated with Ataxic and Non-Ataxic Neurological Dysfunction in SCA3 Patients

  • Jonas Alex Morales SauteEmail author
  • Andrew Chaves Feitosa da Silva
  • Karina Carvalho Donis
  • Leonardo Vedolin
  • Maria Luiza Saraiva-Pereira
  • Laura Bannach Jardim
Letter to the Editor

We read with interest the article recently published in Cerebellum by Klinke et al., entitled “Neuropsychological features of patients with spinocerebellar ataxia (SCA) types 1, 2, 3, and 6,” particularly because it pertains to the depressive mood scores obtained in those patients [1]. SCAs are a group of autosomal dominant ataxic disorders affecting mainly the cerebellum and its afferent and efferent connections; however, in most SCAs the consecutive degenerative process also involves extracerebellar structures [2].

A recent survey of subjective health status performed in 526 SCA patients from the European Integrated Project on Spinocerebellar Ataxias (EUROSCA) clinical group, found that 46% of those patients reported depression/anxiety problems, which was one of the three independent predictors of subjective health status together with ataxia severity and extent of noncerebellar involvement [3]. We previously reported that SCA3 symptomatic patients have higher depressive mood scores...

Keywords

Depressive Symptom Beck Depression Inventory Spinocerebellar Ataxia Beck Depression Inventory Score SCA3 Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This research was supported by the Brazilian funding agencies FIPE-HCPA, CNPq, INAGEMP and FAPERGS.

Financial Disclosure

None of the authors declared a conflict of interest.

References

  1. 1.
    Klinke I, Minnerop M, Schmitz-Hübsch T, Hendriks M, Klockgether T, Wüllner U, et al. Neuropsychological features of patients with spinocerebellar ataxia (SCA) types 1, 2, 3, and 6. Cerebellum. 2010. [Epub ahead of print]Google Scholar
  2. 2.
    Schöls L, Bauer P, Schmidt T, Schulte T, Riess O. Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis. Lancet Neurol. 2004;3:291–304.CrossRefPubMedGoogle Scholar
  3. 3.
    Schmitz-Hübsch T, Coudert M, Giunti P, Globas C, Baliko L, Fancellu R, et al. Self-rated health status in spinocerebellar ataxia—results from a European multicenter study. Mov Disord. 2010;5:587–95.Google Scholar
  4. 4.
    Cecchin CR, Pires AP, Rieder CR, Monte TL, Silveira I, Carvalho T, et al. Depressive symptoms in Machado–Joseph disease (SCA-3): patients and their relatives. Community Genet. 2007;10:19–26.CrossRefPubMedGoogle Scholar
  5. 5.
    Bauer PO, Kotliarova SE, Matoska V, Musova Z, Hedvicakova P, Boday A, et al. Fluorescent multiplex PCR—fast method for autosomal dominant spinocerebellar ataxias screening. Genetika. 2005;41:830–7.PubMedGoogle Scholar
  6. 6.
    Gorenstein C, Andrade L. Validation of a Portuguese version of the Beck Depression Inventory and the state–trait anxiety inventory in Brazilian subjects. Braz J Med Biol Res. 1996;29:453–7.PubMedGoogle Scholar
  7. 7.
    Schmitz-Hübsch T, du Montcel ST, Baliko L, Berciano J, Boesch S, Depondt C, et al. Scale for the assessment and rating of ataxia: development of a new clinical scale. Neurology. 2006;66:1717–20.CrossRefPubMedGoogle Scholar
  8. 8.
    Kieling C, Rieder CR, Silva AC, Saute JA, Cecchin CR, Monte TL, et al. A neurological examination score for the assessment of spinocerebellar ataxia 3 (SCA3). Eur J Neurol. 2008;15:371–6.CrossRefPubMedGoogle Scholar
  9. 9.
    Vedolin L, Schwartz IV, Komlos M, Schuch A, Azevedo AC, Vieira T, et al. Brain MRI in mucopolysaccharidosis: effect of aging and correlation with biochemical findings. Neurology. 2007;69:917–24.CrossRefPubMedGoogle Scholar
  10. 10.
    Rüb U, Brunt ER, Deller T. New insights into the pathoanatomy of spinocerebellar ataxia type 3 (Machado–Joseph disease). Curr Opin Neurol. 2008;21:111–6.CrossRefPubMedGoogle Scholar
  11. 11.
    Silva RCR, Saute JA, Silva ACF, Coutinho ACO, Saraiva-Pereira ML, Jardim LB. Occupational therapy in spinocerebellar ataxia type 3: an open-label trial. Braz J Med Biol Res. 2010 [Epub ahead of print]Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Jonas Alex Morales Saute
    • 1
    • 2
    Email author
  • Andrew Chaves Feitosa da Silva
    • 3
  • Karina Carvalho Donis
    • 3
  • Leonardo Vedolin
    • 4
  • Maria Luiza Saraiva-Pereira
    • 3
  • Laura Bannach Jardim
    • 1
    • 3
    • 5
  1. 1.Postgraduate Program in Medical SciencesUniversidade Federal do Rio Grande do SulPorto AlegreBrazil
  2. 2.Neurology ServiceHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  3. 3.Medical Genetics ServiceHospital de Clínicas de Porto AlegrePorto AlegreBrazil
  4. 4.Neuroradiology ServiceHospital Moinhos de VentoPorto AlegreBrazil
  5. 5.Department of Internal MedicineUniversidade Federal do Rio Grande do SulPorto AlegreBrazil

Personalised recommendations