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The Cerebellum

, Volume 9, Issue 3, pp 398–404 | Cite as

Interhemispheric Asymmetry of Corticomotor Excitability After Chronic Cerebellar Infarcts

  • Suzete Nascimento Farias da GuardaEmail author
  • Leonardo G. Cohen
  • Marco da Cunha Pinho
  • Fábio Iuji Yamamoto
  • Paulo Eurípedes Marchiori
  • Milberto Scaff
  • Adriana Bastos Conforto
Article

Abstract

Early after stroke, there is loss of intracortical facilitation (ICF) and increase in short-interval intracortical inhibition (SICI) in the primary motor cortex (M1) contralateral to a cerebellar infarct. Our goal was to investigate intracortical M1 function in the chronic stage following cerebellar infarcts (>4 months). We measured resting motor threshold (rMT), SICI, ICF, and ratios between motor-evoked potential amplitudes (MEP) and supramaximal M response amplitudes (MEP/M; %), after transcranial magnetic stimulation was applied to the M1 contralateral (M1contralesional) and ipsilateral (M1ipsilesional) to the cerebellar infarct in patients and to both M1s of healthy age-matched volunteers. SICI was decreased in M1contralesional compared to M1ipsilesional in the patient group in the absence of side-to-side differences in controls. There were no significant interhemispheric or between-group differences in rMT, ICF, or MEP/M (%). Our results document disinhibition of M1contralesional in the chronic phase after cerebellar stroke.

Keywords

Transcranial magnetic stimulation Paired pulse Cerebellar disease Stroke 

Notes

Acknowledgments

Dr. Suzete N. Farias received a research scholarship from Fundação Faculdade de Medicina, Clinics Hospital/São Paulo University. We thank Michael Dimyan for helpful comments and suggestions.

Conflict of Interest

The authors have no conflicts of interest.

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  • Suzete Nascimento Farias da Guarda
    • 1
    • 2
    • 6
    Email author
  • Leonardo G. Cohen
    • 3
  • Marco da Cunha Pinho
    • 4
  • Fábio Iuji Yamamoto
    • 1
  • Paulo Eurípedes Marchiori
    • 1
  • Milberto Scaff
    • 1
  • Adriana Bastos Conforto
    • 1
    • 2
    • 5
  1. 1.Department of NeurologyClinics Hospital/São Paulo UniversitySão PauloBrazil
  2. 2.Neurostimulation LaboratoryClinics Hospital/São Paulo UniversitySão PauloBrazil
  3. 3.Human Cortical Physiology and Stroke Neurorehabilitation SectionNINDS, NIHBethesdaUSA
  4. 4.Department of RadiologyClinics Hospital/São Paulo UniversitySão PauloBrazil
  5. 5.Instituto Israelita de Ensino e Pesquisa Albert EinsteinSão PauloBrazil
  6. 6.BahiaBrazil

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