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Plasma cell leukemia masquerading as lymphoplasmacytic lymphoma: a diagnostic challenge

  • Praveen Sharma
  • Ankur Jain
  • Prashant SharmaEmail author
  • Man Updesh Singh Sachdeva
  • Neelam Varma
  • Pankaj Malhotra
Letter to the editor
  • 5 Downloads

Dear Editor,

We read with interest the case report by Larson et al. [1] in the Journal of Hematopathology and would like to share a similarly challenging case of plasma cell leukemia encountered in a young patient at our center.

A 36-year-old lady presented with a history of backache and generalized weakness for 3 months. She had severe pallor; however, there was no localized bony tenderness, lymphadenopathy, or organomegaly. Investigations revealed hemoglobin 51 g/L (reference range 120–160 g/L), total leukocyte count 243 × 10 9/L (reference range 4–11 × 10 9/L), and platelets 119 × 10 9/L (reference range 150–400 × 10 9/L). A peripheral blood smear showed marked lymphocytosis with absolute lymphocyte count of 206.6 × 10 9/L (reference range 1.0–4.0 × 10 9/L) and 3% cells showing lymphoplasmacytic morphology (Fig.  1, left image). Biochemistry revealed normal renal function, albumin-corrected serum calcium (10.3 mg/dL, reference range 9–11 mg/dL), and elevated lactate dehydrogenase...

Notes

Compliance with ethical standards

Conflicting interest

The authors declare that they have no conflict of interest.

References

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    Larson DP, Wood AJ, Hoyer JD (2018) Nonconventional morphology in plasma cell leukemia. J Hematop 11:127–128CrossRefGoogle Scholar
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    Loureiro AD, Gonçalves MV, Ikoma MR, Silva MR, Colleoni GW, Chauffaille ML et al (2017) Plasma cell leukemia with t(11;14)(q13;q32) simulating lymphoplasmacytic lymphoma - a diagnostic challenge solved by flow cytometry. Rev Bras Hematol Hemoter 39:66–69CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of HematologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Department of Internal MedicinePostgraduate Institute of Medical Education and ResearchChandigarhIndia

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