Journal of Hematopathology

, Volume 8, Issue 1, pp 37–41 | Cite as

Clinicopathologic features of primary colonic enteropathy-associated T cell lymphoma type II in an elderly Asian male with diarrhea

  • Jey-Hsin Chen
  • Diane Bai
  • Vik Dabhi
  • Brent L. Wood
  • Steven J. Kussick
Case Report


A 76-year-old Asian man with a 6-month history of intractable watery diarrhea proceeded to colonoscopic examination that revealed diffusely dull-appearing colonic mucosa with focal areas of superficial ulceration. Mucosal biopsies demonstrated a neoplastic population of monomorphous small-to-intermediate-sized CD8+/CD56+ cytotoxic T cells that densely infiltrated the surface epithelium and crypts in a near pan-colonic distribution without tumor formation. Clinical staging revealed no disease elsewhere. The patient was treated aggressively with chemotherapy but died from disease five and a half months after presentation. In all likelihood, the patient had primary colonic involvement by enteropathy-associated T cell lymphoma (EATL) type II, a rare and aggressive extranodal non-Hodgkin lymphoma that occurs more commonly in Asians in whom celiac disease is infrequent. Widespread colonic disease in the absence of a mass-forming infiltrate has not been characterized in EATL type II and highlights an expanded clinical and pathological spectrum of the disease.


Enteropathy-associated T cell lymphoma (EATL) Primary intestinal T cell lymphoma (ITL) Monomorphic Cytotoxic T cells Natural killer (NK) cells 



Enteropathy-associated T cell lymphoma


Primary intestinal T-cell lymphoma


Natural killer


Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2015

Authors and Affiliations

  • Jey-Hsin Chen
    • 1
    • 2
  • Diane Bai
    • 3
  • Vik Dabhi
    • 4
  • Brent L. Wood
    • 5
    • 6
  • Steven J. Kussick
    • 7
  1. 1.CellNetix Pathology and LaboratoriesSeattleUSA
  2. 2.Swedish Medical CenterSeattleUSA
  3. 3.Division of GastroenterologyPacific Medical CenterSeattleUSA
  4. 4.Division of Hematology and OncologyPacific Medical CenterSeattleUSA
  5. 5.Department of Laboratory MedicineUniversity of Washington Medical CenterSeattleUSA
  6. 6.Seattle Cancer Care AllianceSeattleUSA
  7. 7.PhenoPath LaboratoriesSeattleUSA

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