Journal of Hematopathology

, Volume 6, Issue 3, pp 151–153 | Cite as

Intraosseous hibernoma or unusual location of brown fat?

  • David T. Lynch
  • Raetasha S. Dabney
  • Jared M. Andrews
Case Report


The hibernoma is a rare benign tumor of brown fat. It is most commonly found subcutaneously in the thigh, shoulder, and back of middle-aged adults. Intraosseous hibernomas and brown fat are rarely reported. There are currently two reported cases in the literature, one of which occurred in the setting of essential thrombocythemia (ET). We report an intraosseous brown fat infiltrate found incidentally in a bone marrow biopsy of a 77-year-old female with ET.


Brown adipose tissue Hibernoma Intraosseous hibernoma 


  1. 1.
    Lichtenbelt W, Vanhommerig J, Smulders N et al (2009) Cold-activated brown adipose tissue in healthy men. N Engl J Med 360(15):1500–1508CrossRefGoogle Scholar
  2. 2.
    Furlong M, Fanburg-Smith J, Miettinen M (2001) The morphologic spectrum of hibernoma. Am J Surg Pathol 25(6):809–814PubMedCrossRefGoogle Scholar
  3. 3.
    Gaffney E, Hargreaves H, Semple E, Vellios F (1982) Hibernoma: distinctive light and electron microscopic features and relationship to brown adipose tissue. Hum Pathol 14(8):677–687CrossRefGoogle Scholar
  4. 4.
    Mertens F, Rydholm A, Brosjo O, Willen H, Mitelman F, Mandahl N (1994) Hibernomas are characterized by rearrangements of chromosome bands 11q13-21. Int J Cancer 58:503–505PubMedCrossRefGoogle Scholar
  5. 5.
    Mrozek K, Karakousis C, Bloomfield C (1994) Band 11q13 is nonrandomly rearranged in hibernomas. Gene Chromosome Cancer 9:145–147CrossRefGoogle Scholar
  6. 6.
    Kumar R, Deaver M, Czerniak B, Madewell J (2011) Intraosseous hibernoma. Skeletal Radiol 40:641–645PubMedCrossRefGoogle Scholar
  7. 7.
    Thorns C, Schardt C, Katenkamp D, Kahler C, Merz H, Feller A (2007) Hibernoma-like brown fat in the bone marrow: report of a unique case. Virchows Arch 452(3):343–345CrossRefGoogle Scholar
  8. 8.
    Rosso R, Lucioni M (2006) Normal and neoplastic cells of brown adipose tissue express the adhesion molecule CD31. Arch Pathol Lab Med 130:480–482PubMedGoogle Scholar
  9. 9.
    Lele S, Chundru S, Chaljub G, Adegboyega P, Haque A (2002) Hibernoma: a report of 2 unusual cases with a review of the literature. Arch Pathol Lab Med 126:975–978PubMedGoogle Scholar

Copyright information

© Springer-Verlag 2012

Authors and Affiliations

  • David T. Lynch
    • 1
  • Raetasha S. Dabney
    • 2
  • Jared M. Andrews
    • 1
  1. 1.Department of PathologySan Antonio Military Medical CenterSan AntonioUSA
  2. 2.Department of Hematology and OncologySan Antonio Military Medical CenterSan AntonioUSA

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