NK cell lymphoma, nasal type, with massive lung involvement: a case report
- First Online:
- 67 Downloads
Extranodal NK/T cell lymphoma, nasal type, is an Epstein–Barr virus-associated lymphoma that most commonly involves the nasal cavity and upper respiratory tract. Lung involvement by NK/T cell lymphoma is rare and seldom reported in the literature. We describe the unusual case of a 41-year-old male with NK cell lymphoma, nasal type, who presented with massive secondary lung involvement 2.5 years after the detection of a retroperitoneal mass. The diagnosis was made by open lung biopsy. Despite aggressive treatment, the patient died shortly after the initiation of therapy. Lung involvement by NK/T cell lymphoma occurs most commonly as part of widely disseminated disease and carries a poor prognosis for the patient. Novel agents and innovative therapies need to be developed for this aggressive lymphoma.
KeywordsExtranodal NK/T lymphoma Lung involvement Epstein–Barr virus
- 1.Chan JKC, Quintanilla-Martinez L, Ferry JA, Peh SC (2008) Extranodal NK/T-cell lymphoma, nasal type. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (eds) World Health Organization classification of tumors: tumors of haematopoietic and lymphoid tissues. IARC, Lyon, pp 285–288Google Scholar
- 6.Aviles A, Neri N, Fernandez R et al (2003) Nasal NK/T-cell lymphoma with disseminated diseases treated with aggressive combined therapy. Med Oncol 20:2013–2017Google Scholar