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Cancer Microenvironment

, Volume 8, Issue 3, pp 167–176 | Cite as

The Role of Mast Cells in Molding the Tumor Microenvironment

  • A. Rigoni
  • M. P. ColomboEmail author
  • C. Pucillo
Original Paper

Abstract

Mast cells (MCs) are granulocytic immune cells that reside in tissues exposed to the external environment. MCs are best known for their activity in allergic reactions, but they have been involved in different physiological and pathological conditions. In particular, MC infiltration has been shown in several types of human tumors and in animal cancer models. Nevertheless, the role of MCs in the tumor microenvironment is still debated because they have been associated either to good or poor prognosis depending on tumor type and tissue localization. This dichotomous role relies on MC capacity to secrete a broad spectrum of molecules with modulatory functions, which may condition the final tumor outcome also promoting angiogenesis and tissue remodeling. In this review, we analyze the multifaceted role of mast cell in tumor progression and inhibition considering their ability to interact with: i) immune cells, ii) tumor cells and iii) the extracellular matrix. Eventually, the current MC targeting strategies to treat cancer patients are discussed. Deciphering the actual role of MCs in tumor onset and progression is crucial to identify MC-targeted treatments aimed at killing cancer cells or at making the tumor vulnerable to selected anti-cancer drugs.

Keywords

Mast cell Cancer Immune responses Immunosuppression Extracellular matrix 

Notes

Acknowledgments

This work was supported by grants from Fondazione Cariplo (number 2010-0790) and Associazione Italiana per la Ricerca sul Cancro (AIRC: Investigator Grant number 14194 to Mario Paolo Colombo). The work of Carlo Pucillo is supported by a grant from Associazione Italiana Mastocitosi (ASIMAS). Alice Rigoni is supported by a triennial fellowship from Fondazione Italiana per la Ricerca sul Cancro (FIRC).

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Copyright information

© Springer Science+Business Media Dordrecht 2014

Authors and Affiliations

  1. 1.Molecular Immunology Unit, Department of Experimental Oncology and Molecular MedicineFondazione IRCCS Istituto Nazionale TumoriMilanItaly
  2. 2.Department of Medical and Biological SciencesUniversity of UdineUdineItaly

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