, Volume 97, Issue 2, pp 145–151 | Cite as

One-step arthroscopic technique for the treatment of osteochondral lesions of the knee with bone-marrow-derived cells: three years results

  • Roberto Buda
  • Francesca Vannini
  • Marco CavalloEmail author
  • Matteo Baldassarri
  • Deianira Luciani
  • Antonio Mazzotti
  • Camilla Pungetti
  • Alessandra Olivieri
  • Sandro Giannini
Original Article


Osteochondral lesions of the knee (OLK) are a common cause of knee pain and associated diseases. A new bone-marrow-derived mesenchymal stem cells technique has been developed for the treatment of OLK. 30 patients with OLK underwent arthroscopic one-step procedure. The bone marrow was harvested from the patients’ posterior iliac crest and arthroscopically implanted with a scaffold into the lesion site. Clinical inspection and MRI were performed. Mean International Knee Documentation Committee (IKDC) score before surgery was 29.9 ± 13.2 and 85.4 ± 4.2 at 29 ± 4.1 months (p < 0.0005), while Knee injury and Osteoarthritis Outcome Score (KOOS) before surgery was 35.1 ± 11.9 and 87.3 ± 7.3 at 29 ± 4.1 months (p < 0.0005). Control MRI and bioptic samples showed an osteochondral regeneration of the lesion site. The one-step technique appears to be a good and reliable option for treatment of OLK at three years of follow-up.

Level of evidence Case series, Level IV.


Bone marrow Osteochondral lesion Knee Arthroscopic Mesenchymal Stem cells 


Conflict of interest



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Copyright information

© Istituti Ortopedici Rizzoli 2013

Authors and Affiliations

  • Roberto Buda
    • 1
  • Francesca Vannini
    • 1
  • Marco Cavallo
    • 1
    Email author
  • Matteo Baldassarri
    • 1
  • Deianira Luciani
    • 1
  • Antonio Mazzotti
    • 1
  • Camilla Pungetti
    • 1
  • Alessandra Olivieri
    • 1
  • Sandro Giannini
    • 1
  1. 1.Clinical Orthopaedic and Traumatology Unit IRizzoli Orthopaedic InstituteBolognaItaly

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