African Journal of Urology

, Volume 16, Issue 3, pp 69–72 | Cite as

Testicular biopsies of azoospermic men at the Lagos State University Teaching Hospital

  • S. Odunayo Ikuerowo
  • M. C. Izegbu
  • A. S. Benebo
  • I. O. Fadeyibi
  • F. O. Omodele
Original Article
  • 23 Downloads

Abstract

Objectives

This study was conducted to evaluate the histological findings from testicular biopsies in azoospermic men seen at the Lagos State University Teaching Hospital, Ikeja — Lagos, Nigeria.

Patients and Methods

A retrospective study of testicular biopsies of azoospermic men who presented to our institution from 2005 to 2006 was performed. The patient’s age, type of infertility and histopathological diagnosis were evaluted. All biopsies were preserved in 10% formaldehyde solution.

Results

Of the 51 azoospermic men (mean age 30 years, range 25–46 years) 25 (49.0%) had primary infertility, 11 (21.6%) had secondary infertility and 15 (29.0%) were not specified. Five (9.8%) patients had normal spermatogenesis. Abnormal histological parameters occurred in 46 (90.2%) patients: testicular atrophy in 30 (58.8%), maturation arrest in 14 (27.5%) and hypospermatogenesis in 2 (3.9%) patients.

Conclusion

The presence of normal spermatogenesis in azoospermic men, which would suggest an obstructive lesion, is not common in our practice, in contrast to previous studies from our country. This may indicate a changing pattern in the aetiology of male infertility in our environment. Identification of the possible causes of testicular damage resulting in non-obstructive azoospermia in our environment may help to prevent male infertility.

Key Words

Azoospermia etiology diagnosis testicular biopsies histopathology infertility environment 

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References

  1. 1.
    Report on evaluation of the azoospermic male. Fertil. Steril. 2006;86(5 Suppl.):S 210–215.Google Scholar
  2. 2.
    Thonneau P, Marchand S, Tallec A, Ferial ML, Ducot B, Lansac J, et al. Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988–1989). Hum.Reprod. 1991; Jul;6(6):811–816.PubMedGoogle Scholar
  3. 3.
    Jarow JP, Espeland MA, Lipshultz LI. Evaluation of the azoospermic patient. J.Urol. 1989; Jul;142(1):62–65.PubMedGoogle Scholar
  4. 4.
    Lee JS, Park HJ, Seo JT. What is the indication of varicocelectomy in men with nonobstructive azoospermia? Urology. 2007;69(2):352–355.PubMedCrossRefGoogle Scholar
  5. 5.
    Schlosser J, Nakib I, Carré-Pigeon F, Staerman F. Male infertility: Management strategies [Infertilité masculine: Stratégie de la prise en charge]. Ann.Urol. 2007;41(1):6–11.CrossRefGoogle Scholar
  6. 6.
    Khamsi F, Lacanna I, Endman M, Wong J. Recent advances in assisted reproductive technologies. Endocrine. 1998; Aug;9(1):15–25.PubMedCrossRefGoogle Scholar
  7. 7.
    Martin du Pan RC, Bourrit B. Etiologie et traitement de la sterilite due a une azoospermie. [Etiology and treatment of sterility due to azoospermia]. Rev.Med. Suisse Romande. 1999; Jun;119(6):453–457.PubMedGoogle Scholar
  8. 8.
    Thomas JO. Histological pattern of testicular biopsies in infertile males in Ibadan, Nigeria. East Afr.Med.J. 1990; Aug;67(8):578–584.PubMedGoogle Scholar
  9. 9.
    Obafunwa JO, Elesha SO, Odunjo EO. Mor phological changes found in the testes of 177 Nigerian males investigated for infertility. Afr.J.Med.Med.Sci. 1993; Dec;22(4):35–40.PubMedGoogle Scholar
  10. 10.
    Nagpal BL, Manjari M, Kapoor K, Dhaliwal US. Testicular biopsy in cases of male infertility: A retrospective study. J.Indian Med.Assoc. 1993; Jul;91(7):171–174.PubMedGoogle Scholar
  11. 11.
    Tan KH, Lim PH. Testicular biopsy and scrotal exploration in the management of male infertility. Singapore Med.J. 1991; Feb;32(1):41–46.PubMedGoogle Scholar
  12. 12.
    Thomas JO, Jamal A. Primary testicular causes of infertility. Do environmental and socio-cultural factors have a role? Trop.Geogr.Med. 1995;47(5):203–205.PubMedGoogle Scholar
  13. 13.
    Oliva A, Spira A, Multigner L. Contribution of environmental factors to the risk of male infertility. Hum.Reprod. 2001; Aug;16(8):1768–1776.PubMedCrossRefGoogle Scholar
  14. 14.
    Rowley MJ, Heller CG. The testicular biopsy: Surgical procedure, fixation and staining technics. Fertil.Steril. 1966; Mar–Apr;17(2):177–186.PubMedGoogle Scholar

Copyright information

© PAUSA and Springer Verlag France 2010

Authors and Affiliations

  • S. Odunayo Ikuerowo
    • 1
  • M. C. Izegbu
  • A. S. Benebo
    • 2
  • I. O. Fadeyibi
    • 1
  • F. O. Omodele
    • 1
  1. 1.Department of SurgeryLagos State University Teaching HospitalIkeja - LagosNigeria
  2. 2.Department of Morbid Anatomy and Forensic MedicineLagos State University Teaching HospitalIkeja - LagosNigeria

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