Skip to main content

Advertisement

Log in

A rare case of synovial sarcoma of the prostate

  • Case Report
  • Published:
African Journal of Urology Submit manuscript

Abstract

Prostatic synovial sarcomas are exceedingly rare. To our knowledge, only six primary cases have been reported so far. We herein describe a primary synovial sarcoma of the prostate seen in a 25-year-old male patient, the youngest patient seen with this disease to date. He was referred to our department with the diagnosis of high-grade sarcoma of the prostate revealed by TRUS-guided biopsy. On admission he had a transurethral catheter for acute retention of urine. MRI revealed a solid prostatic tumor of 9.5 × 8 cm involving the rectum without any evidence of lymphatic or distant metastases. The patient underwent total pelvic exenteration and sigmoid end colostomy with ileal conduit. Histopathology revealed a synovial sarcoma of the prostate, immunoreactive to vimentin, Bcl-2 and cytokeratin. The patient is doing well at 18 months follow-up.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Iwasaki H, Ishiguro M, Ohjimi Y, Ikegami H, Takeuchi T, Kikuchi M, et al. Synovial sarcoma of the prostate with t(X;18)(p11.2;q11.2). Am.J.Surg.Pathol. 1999; Feb;23(2):220–226.

    Article  PubMed  CAS  Google Scholar 

  2. Shirakawa T, Fujisawa M, Gotoh A, Okada H, Arakawa S, Kamidono S. Complete resection of synovial sarcoma of prostatic fascia. Urology. 2003; Mar;61(3):644.

    Article  PubMed  Google Scholar 

  3. Williams DH, Hua VN, Chowdhry AA, Laskin WB, Kalapurakal JA, Dumanian GA, et al. Synovial sarcoma of the prostate. J.Urol. 2004; Jun;171(6 Pt 1):2376.

    Article  PubMed  Google Scholar 

  4. Pan CC, Chang YH. Primary synovial sarcoma of the prostate. Histopathology. 2006; Feb;48(3):321–323.

    Article  PubMed  Google Scholar 

  5. Jun L, Ke S, Zhaoming W, Linjie X, Xinru Y. Primary synovial sarcoma of the prostate: Report of 2 cases and literature review. Int.J.Surg.Pathol. 2008; Jul;16(3):329–334.

    Article  PubMed  Google Scholar 

  6. Antonescu CR, Kawai A, Leung DH, Lonardo F, Woodruff JM, Healey JH, et al. Strong association of SYT-SSX fusion type and morphologic epithelial differentiation in synovial sarcoma. Diagn.Mol.Pathol. 2000; Mar;9(1):1–8.

    Article  PubMed  CAS  Google Scholar 

  7. Lubieniecka JM, de Bruijn DR, Su L, van Dijk AH, Subramanian S, van de Rijn M, et al. Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma. Cancer Res. 2008; Jun 1;68(11):4303–4310.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jayesh V. Dhabalia.

About this article

Cite this article

Dhabalia, J.V., Nelivigi, G.G., Singh Punia, M. et al. A rare case of synovial sarcoma of the prostate. Afr J Urol 15, 183–185 (2009). https://doi.org/10.1007/s12301-009-0033-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12301-009-0033-4

Key Words

Navigation