Evaluation of COMT Gene rs4680 Polymorphism as a Risk Factor for Endometrial Cancer

  • Pradeep Kumar
  • Garima Singh
  • Vandana RaiEmail author
Original Research Article


Catechol-O-methyletransferase (COMT) enzyme is involved in the inactivation of catecholamine and catechol estrogens. Catechol estrogens have carcinogenic potential and DNA damaging ability. Several studies investigated COMT Val158Met polymorphism as risk factor for endometrial cancer but the results were inconclusive. Hence the objective of present study was to find out exact association between COMT gene Val158Met polymorphism and endometrial cancer by a meta-analysis. Pubmed, Google Scholar, Springer Link and Science Direct databases were searched for case–control articles which investigated COMT Val158Met polymorphism in endometrial cancer cases. All statistical analysis was performed using MetaAnalyst and Mix programs. The results of meta-analysis suggested that there were no association between COMT Val158Met polymorphism and endometrial cancer risk (allele contrast model—ORA vs. G = 0.97, 95% CI = 0.86–1.10, p = 0.67; co-dominant model—ORAG vs. GG = 0.91, 95% CI = 0.77–1.06, p = 0.23; homozygote model—ORAA vs. GG = 1.01, 95% CI = 0.84–1.19, p = 0.29; dominant model—ORAA+AG vs. GG = 0.93, 95% CI = 0.77–1.11, p = 0.43; recessive model—ORAA vs. AG+GG = 1.02, 95% CI = 0.89–1.20, p = 0.62). Publication bias was absent. Subgroup analysis based on source of controls was also performed. In conclusion, results of present meta-analysis showed no association between COMT Val158Met polymorphism and susceptibility to endometrial cancer.


Endometrial cancer COMT Val158Met Meta-analysis Polymorphism 


Compliance with Ethical Standards

Conflict of interest



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© Association of Clinical Biochemists of India 2018

Authors and Affiliations

  1. 1.Human Molecular Genetics Laboratory, Department of BiotechnologyVBS Purvanchal UniversityJaunpurIndia

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