Indian Journal of Clinical Biochemistry

, Volume 33, Issue 2, pp 239–240 | Cite as

Vanillic Acid in Endometrial Carcinoma: A Role for Nitric Oxide?

  • Salvatore ChirumboloEmail author
  • Geir Bjørklund
Letter to the Editor

To the Editor

The recent article by Bhavani et al. [1], reported that vanillic acid (VA) should prevent the effect of the carcinogen N-methyl-N′-nitro-N-nitroso-guanidine (MNNG) on the induction of endometrial carcinoma in Albino female Wistar rats. The study showed that pre-treatment of animals with 100 mg/kg b.w of vanillic acid before the intra-vaginal introduction of 150 mg/0.2 ml olive oil (750 mg/ml) of MNNG, reduced by 70% the tumor incidence [1]. This reduction has to be most probably attributed to the effect of VA, as the protocol in which VA and MNNG were up-taken together by rats in the same experimental setting, did not succeed in reducing tumor incidence with the same extent [1]. The paper by Bhavani et al. [1], showed that VA fundamentally affected the plasma level of some markers of the oxidative stress response, i.e. reducing LOOH and SOD (lipid hydro-peroxides and superoxide dismutase) and much more moderately affecting CYP450 (increase), CAT, GPx and GSH (decrease)....


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.


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Copyright information

© Association of Clinical Biochemists of India 2017

Authors and Affiliations

  1. 1.Department of Neurological and Movement SciencesUniversity of VeronaVeronaItaly
  2. 2.Council for Nutritional and Environmental Medicine (CONEM)Mo i RanaNorway

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