Vanillic Acid in Endometrial Carcinoma: A Role for Nitric Oxide?
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The recent article by Bhavani et al. , reported that vanillic acid (VA) should prevent the effect of the carcinogen N-methyl-N′-nitro-N-nitroso-guanidine (MNNG) on the induction of endometrial carcinoma in Albino female Wistar rats. The study showed that pre-treatment of animals with 100 mg/kg b.w of vanillic acid before the intra-vaginal introduction of 150 mg/0.2 ml olive oil (750 mg/ml) of MNNG, reduced by 70% the tumor incidence . This reduction has to be most probably attributed to the effect of VA, as the protocol in which VA and MNNG were up-taken together by rats in the same experimental setting, did not succeed in reducing tumor incidence with the same extent . The paper by Bhavani et al. , showed that VA fundamentally affected the plasma level of some markers of the oxidative stress response, i.e. reducing LOOH and SOD (lipid hydro-peroxides and superoxide dismutase) and much more moderately affecting CYP450 (increase), CAT, GPx and GSH (decrease)....
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The authors declare that they have no conflict of interest.
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