Association of Metabolic Syndrome and Oxidative DNA Damage in HIV/AIDS Patients
HIV-infected adults may be likely to have metabolic syndrome (MS) at younger ages and in the absence of obesity compared with general population. In the present study, we determined prevalence of MS and its association with oxidative deoxy nucleic acid (DNA) damage in HIV-1 infected patients with different ART status. We used plasma level of the oxidized base, 8-hydroxy-2-deoxyguanosine (8-OHdG), as a biomarker of oxidative DNA damage. To measure plasma 8-OHdG we used 8-OHdG enzyme-linked, immunosorbent assay. The biomarkers of MS were insulin resistance, Cholesterol/HDL ratio, Waist circumference and Hypertension. MS and oxidative DNA damage were significantly higher in HIV-positive patients with second line ART and first line ART than ART-naive patients. In a logistic regression analysis, increased MS was positively associated with the increased DNA damage (OR: 29.68, 95%:13.47, CI: 65.40) P = 0.0001. ART plays a significant role in the development of MS and oxidative DNA damage in HIV-positive patients taking antiretroviral therapy. Awareness and knowledge of MS and DNA damage in HIV/AIDS patients may prove helpful to clinicians to manage non-AIDS diseases such as cardiovascular disease and cancer. To determine exact role of ART in induction of MS and DNA damage larger studies are warranted.
KeywordsDNA damage Human immunodeficiency virus (HIV) infection Insulin resistance Metabolic syndrome 8-OH-dG
National AIDS Control Organisation (NACO) Delhi, Mumbai District AIDS Control Society (MDACS) Mumbai and ART Centre Sir J J Group of Hospitals Mumbai supported this study.
Compliance with Ethical Standards
Conflict of interest
All authors declared that there are no conflicts of interest in this manuscript.
- 9.Gundurao Sreekantamurthy G, Singh NB, Singh Th Bhimo, et al. Study of body composition and metabolic parameters in HIV-1male patients. J Nutr Metab. 2014;498497:5.Google Scholar
- 24.Ndona MM, Longo-Mbenza B, et al. Nadir CD4+, religion, antiretroviral therapy, incidence of type 2 diabetes mellitus, and increasing rates of obesity among black Africans with HIV disease. Int J Gen Med. 2012;5:983–90.Google Scholar