Indian Journal of Clinical Biochemistry

, Volume 30, Issue 2, pp 187–193 | Cite as

Effect of L-carnitine Supplementation on Nutritional Status and Physical Performance Under Calorie Restriction

  • Swati Jain
  • Som Nath SinghEmail author
Original Article


L-carnitine is popular as a potential ergogenic aid because of its role in the conversion of fat into energy. The present study was undertaken to investigate the effect of short term supplementation of L-carnitine on metabolic markers and physical efficiency tests under short term calorie restriction. Male albino rats were divided into four groups (n = 12 in each)—control, calorie restricted (CR for 5 days, 25 % of basal food intake), L-carnitine supplemented (CAR, given orally for 5 days at a dose of 100 mg/kg), CR with L-carnitine supplementation (CR + CAR). Food intake and body weight of the rats were measured along with biochemical variables like blood glucose, tissue glycogen, plasma and muscle protein and enzymatic activities of CPT-1 (carnitine palmitoyl transferase-1) and AMP kinase. Results demonstrated that L-carnitine caused marked increase in muscle glycogen, plasma protein, CPT-1 activity and swim time of rats (P < 0.05) on short term supplementation. In addition to the substantive effects caused by CR alone, L-carnitine under CR significantly affected muscle glycogen, plasma protein, CPT-1 activity and AMP kinase (P < 0.05). Short term CR along with L-carnitine also resulted in increased swim time of rats than control, CR and L-carnitine treated rats (P < 0.05). The present study was an attempt towards developing an approach for better adherence to dietary restriction regimen, with the use of L-carnitine.


L-carnitine Calorie restriction Forced swim test Carnitine palmitoyl transferase-1 AMP kinase Glycogen 



Authors are thankful to DIPAS, Defence Research and Development Organisation (DRDO) for the financial support of the study.


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Copyright information

© Association of Clinical Biochemists of India 2014

Authors and Affiliations

  1. 1.Nutrition DivisionDefence Institute of Physiology and Allied SciencesDelhiIndia

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