Indian Journal of Clinical Biochemistry

, Volume 26, Issue 4, pp 360–365

Efficacy of a Fish Protein Hydrolysate in Malnourished Children

  • Knut Olav Nesse
  • A. P. Nagalakshmi
  • P. Marimuthu
  • Mamta Singh
Original Article


Protein hydrolysates are good nutritional supplements as their bioactive ingredients can be easily absorbed and utilized for various metabolic activities. A fish protein hydrolysate (Amizate), prepared by a unique process of hydrolysis has the advantage of high di/tri peptide content (<10 kDa) along with essential and non essential amino acids, micronutrients and vitamins. The effect of Amizate on malnourished children (6–8 years, a total of 438) of Grade I and II (Gomez’s classification) with respect to immunoglobulins, CD4/CD8 ratios and hemoglobin was examined. Measurement of these parameters during the user trial study (at the beginning and the end after 4 months) indicated that the levels of the immunological parameters were not significantly altered by the Amizate treatment. The values of immunoglobulins and CD4/CD8 ratios of malnourished children (India) are in the normal range and are in accordance with the reported values of various ethnic groups.


Protein hydrolysates Immunoglobulin Malnourishment Nutrition 

Supplementary material

12291_2011_145_MOESM1_ESM.ppt (606 kb)
Supplementary material 1 (PPT 603 kb)


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Copyright information

© Association of Clinical Biochemists of India 2011

Authors and Affiliations

  • Knut Olav Nesse
    • 1
  • A. P. Nagalakshmi
    • 2
  • P. Marimuthu
    • 3
  • Mamta Singh
    • 4
    • 5
  1. 1.Zymtech Production ASLesjaNorway
  2. 2.Consortium Clinical Research Pvt. LtdTamil NaduIndia
  3. 3.Department of BiostatisticsNational Institute of Mental Health and Neuro Sciences (NIMHANS)BangaloreIndia
  4. 4.Jamia Milia IslamiaNew DelhiIndia
  5. 5.Plant Pathology DivisionIndian Agricultural Research Institute, Pusa CampusNew DelhiIndia

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