Indian Journal of Clinical Biochemistry

, Volume 26, Issue 3, pp 309–311

C-Reactive Protein and Uric Acid Levels in Patients with Psoriasis

Brief Communication

Abstract

Serum CRP and uric acid levels were estimated in twenty-five patients with psoriasis (group III) before and after 12 weeks of treatment. Results were compared with a group of 25 normal subjects (group I) and a group of 25 patients of various skin diseases other than psoriatic lesion (group II). Mean value for CRP was found to be increased by more than 20 folds in patients with psoriasis, which was subsequently reduced to nearly 50% of the initial value after 12 weeks of treatment. These patients also showed hyperuricemia. Nearly 25% of these patients also exhibited arthritis. It is thus suggested that both CRP and uric acid levels should be monitored in patients with psoriasis.

Keywords

CRP Uric acid Psoriasis 

References

  1. 1.
    Pepys MB, Hirschfield GM. C-reative protein: a critical update. J Clin Invest. 2003;111:1805–12.PubMedGoogle Scholar
  2. 2.
    Paller D, Petrou I. Pediatric psoriasis: C-reactive protein levels associated with disease severity. J Invest Dermatol. 2009;102:219–27.Google Scholar
  3. 3.
    Strober B, Teller C, Yamauchi P, Miller JL, Hopper M, Yang YC, et al. C-reactive protein levels in psoriasis and psoriatic arthritis. Br J Dermatol. 2008;159:322–30.PubMedCrossRefGoogle Scholar
  4. 4.
    Choi HK, Atkinson K, Karlson EW, Willett W, Curhan G. Purine rich foods and the risk of gout in men. N Eng J Med. 2004;350:1093–103.CrossRefGoogle Scholar
  5. 5.
    Brodov Y, Behar S, Goldenberg I, Boyko V, Churaqui P. Usefulness of combining serum uric acid and C-reactive protein for risk stratification of patients with coronary artery disease. Am J Cardiol. 2009;104:194–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Johnson AM, Rohlfs EM, Silverman LM. Proteins. In: Burtis CA, Ashwood ER, editors. Teitz fundamentals of clinical chemistry. 5th ed. Philadelphia: WB Saunders; 2001. p. 325–51.Google Scholar
  7. 7.
    Evans RP. Manual and automated methods for measuring urea based on modification of its reaction with diacetylmonoxime and semicarbazide. J Clin Path. 1968;21:527–9.PubMedCrossRefGoogle Scholar
  8. 8.
    King EJ. Practical clinical enzymology. London: van Nostrand; 1965. p. 56–61.Google Scholar
  9. 9.
    Vaishnavi C. C-reactive protein in bacterial infections. Immunol Infect Dis J. 1996;6:139–44.Google Scholar
  10. 10.
    Trivedi RC, Rebar L, Berka ES. Uric acid enzymatic method. Clin Chem. 1978;14:1908–12.Google Scholar
  11. 11.
    Dahi MG, Gregory MM, Scheuer PJ. Liver function tests in patients with psoriasis. Br J Med. 1971;57:625–30.CrossRefGoogle Scholar
  12. 12.
    Rocha PP, Santos SA, Rebelo A, Figueiredo A, Quintanilha A, Teixeira F. The inflammatory response in mild and severe psoriasis. Br J Dermatol. 2004;5:50–1.Google Scholar
  13. 13.
    Eroglu ES, Sade L, Yildirir A, Demir O, Bozbas H, Muderrisoglu H. Serum levels of C-reactive protein and uric acid in patients with cardiac syndrome X. Acta Cardiol. 2009;64:207–11.PubMedCrossRefGoogle Scholar
  14. 14.
    Howard D, Sesso JE, Gavin J, Paul M. C-reactive protein and the risk of developing hypertension. JAMA. 2003;290:2945–51.CrossRefGoogle Scholar
  15. 15.
    Leczinsky TM. Inflammation and role of CRP in psoriasis. N Engl J Med. 2005;325:1672–9.Google Scholar

Copyright information

© Association of Clinical Biochemists of India 2011

Authors and Affiliations

  1. 1.Postgraduate Institute of Medical SciencesPt. B. D. Sharma University of Health SciencesRohtakIndia
  2. 2.Maharaja Agrasen Medical CollegeHisarIndia

Personalised recommendations