Indian Journal of Clinical Biochemistry

, Volume 25, Issue 3, pp 273–279

Leucine125Valine (Leu125Val) Gene Polymorphism of Platelet Endothelial Cell Adhesion Molecule-1 (PECAM-1) and Myocardial Infarction in Indian Population

  • Kavita K. Shalia
  • Manoj R. Mashru
  • Surendra L. Soneji
  • Vinod K. Shah
  • Satchidanand Payannavar
  • Amar Walvalkar
  • Rajashree A. Mokal
  • Shilpa M. Mithbawkar
  • Ketki V. Kudalkar
  • Ajin Abraham
  • Priti K. Thakur
Original Article

DOI: 10.1007/s12291-010-0063-5

Cite this article as:
Shalia, K.K., Mashru, M.R., Soneji, S.L. et al. Indian J Clin Biochem (2010) 25: 273. doi:10.1007/s12291-010-0063-5

Abstract

Platelet-endothelial cell adhesion molecule-1 (PECAM-1) has role in atherosclerotic plaque development as well as in thrombosis leading to myocardial infarction (MI). Present study was aimed to analyse the association of PECAM-1 Leu125Val gene polymorphism with MI in Indian population. Subjects included healthy individuals as control (N = 116) and MI patients (N = 100) divided into two groups; MI patients at presentation of the acute event (MI-Group-1, N = 46) and patients with recent event of MI stabilized with treatment 4.5 days from their symptoms (MI-Group-2, N = 54). The difference in the distribution of Leu125Val genotype frequencies of controls and patients did not reach statistical significance. However Leu allele frequency (0.57) was more associated with MI patients as compared to control (0.504). sPECAM-1 levels were significantly elevated in patients at acute event of MI (MI-Group-1) by 44.1% (P = 0.009) as compared to controls and by 95.2% (P = 0.001) as compared to stabilized MI patients (MI-Group-2).

Keywords

Myocardial infarction Gene polymorphism Platelet endothelial cell adhesion molecule-1 

Copyright information

© Association of Clinical Biochemists of India 2010

Authors and Affiliations

  • Kavita K. Shalia
    • 1
  • Manoj R. Mashru
    • 2
  • Surendra L. Soneji
    • 2
  • Vinod K. Shah
    • 2
  • Satchidanand Payannavar
    • 3
  • Amar Walvalkar
    • 3
  • Rajashree A. Mokal
    • 1
  • Shilpa M. Mithbawkar
    • 1
  • Ketki V. Kudalkar
    • 1
  • Ajin Abraham
    • 1
  • Priti K. Thakur
    • 1
  1. 1.Sir H. N. Medical Research Society, Sir H. N. Hospital and Research CentreMumbaiIndia
  2. 2.Department of CardiologySir H. N. Hospital and Research CentreMumbaiIndia
  3. 3.Department of CardiologyRajawadi Municipal HospitalMumbaiIndia

Personalised recommendations