Indian Journal of Clinical Biochemistry

, Volume 25, Issue 2, pp 109–110 | Cite as

Immunomodulators of helminthes: Promising therapeutics for autoimmune disorders and allergic diseases x

  • M. V. R. ReddyEmail author


  1. 1.
    Patel SP, Jarvelin MR, Little MP. Systematic review of worldwide variations of the prevalence of wheezing symptoms in children. Environ Health 2008;7:57.CrossRefPubMedGoogle Scholar
  2. 2.
    Weinstock JV, Elliott DE. Helminths and the IBD hygiene hypothesis. Inflamm Bowel Dis 2009;15:128–133.CrossRefPubMedGoogle Scholar
  3. 3.
    Sewell DL, Reinke EK, Hogan LH, Sandor M, Fabry Z. Immunoregulation of CNS autoimmunity by helminth and mycobacterial infections. Immunol Lett 2002;82:101–110.CrossRefPubMedGoogle Scholar
  4. 4.
    Wills-Karp M, Santeliz J, Karp CL. The germless theory of allergic disease: revisiting the hygiene hypothesis. NatRevImmunol 2001;1:69–75.Google Scholar
  5. 5.
    Weinstock JV, Elliott DE. Helminths and the IBD hygiene hypothesis. Inflamm Bowel Dis 2009;15:128–133.CrossRefPubMedGoogle Scholar
  6. 6.
    Maizels RM, Pearce EJ, Artis D, Yazdanbakhsh M, Wynn TA. Regulation of pathogenesis and immunity in helminth infections. J Exp Med 2009;206(10):2059–2066.CrossRefPubMedGoogle Scholar
  7. 7.
    Nutman TB, Kumaraswami V. Regulation of the immune response in lymphatic filariasis: perspectives on acute and chronic infection with Wuchereria bancrofti in South India. Parasit Immunol ( 2001);28:389–399.CrossRefGoogle Scholar
  8. 8.
    Dunne DW, Cooke A. A worm’s eye view of the immune system: Consequences for evolution of human autoimmune disease. Nat Rev Immunol 2005;5:420–426.CrossRefPubMedGoogle Scholar
  9. 9.
    Maizels RM. Infections and allergy: Helminths, hygiene and host immune regulation. Curr Opin Immunol 2005;17:656–661.CrossRefPubMedGoogle Scholar
  10. 10.
    Trujillo-Vargas CM, Werner-Klein M, Wohlleben G, Polte T, Hansen G, Ehlers S, Erb KJ. Helminth-derived products inhibit the development of allergic responses in mice. Am J Respir Crit Care Med 2007;175(4):336–344.CrossRefPubMedGoogle Scholar
  11. 11.
    Harnett W, McInnes IB, Harnett MM. ES-62, a filarial nematodederived immunomodulator with anti-inflammatory potential. Immunology Letters 2004;94(1–2):27–33.CrossRefPubMedGoogle Scholar
  12. 12.
    Zaccone P, Zoltán Fehérvári1, Jones FM, Sidobre S, Kronenberg M, Dunne DW, Cooke A. Schistosoma mansoni antigens modulate the activity of the innate immune response and prevent onset of type 1 diabetes. Eur J Immunol 2003;33:1439–1449.CrossRefPubMedGoogle Scholar
  13. 13.
    Yang J, Zhao J, Yang Y, Zhang L, Yang X, Zhu X, Ji M, Sun N, Su C. Schistosoma japonicum egg antigens stimulate CD4+ CD25+ T cells and modulate airway inflammation in a murine model of asthma. Immunol 2007;120:8–18.CrossRefGoogle Scholar
  14. 14.
    Elliott DE, Li J, Blum A, Metwali A, Qadir K, Urban JF Jr, Weinstock JV. Exposure to schistosome eggs protects mice from TNBS induced colitis. AJP-GI 2003; 00049.2002Google Scholar
  15. 15.
    Oshiro TM, Macedo MS, Macedo-Soares MF. Anti-inflammatory activity of PAS-1, a protein of Ascaris suum. Inflammation Res 2005;54:17–21CrossRefGoogle Scholar
  16. 16.
    Schierack P, Lucius R, Sonnenburg B, Schilling K, Hartmann S. Parasite-Specific Immunomodulatory Functions of Filarial Cystatin. Infection and Immunity 2003;2422–2429.Google Scholar
  17. 17.
    Summers RW, Elliott DE, Urban JF Jr, Thompson RA, Weinstock JV. Trichuris suis therapy for active ulcerative colitis: a randomized controlled trial. Gastroenterol 2005;128(4):825–832.CrossRefGoogle Scholar
  18. 18.
    Croese J, O’neil J, Masson J, Cooke S, Melrose W, Pritchard D, Speare R. A proof of concept study establishing Necator americanus in Crohn’s patients and reservoir donors. Gut 2006; 55(1):136–137.CrossRefPubMedGoogle Scholar

Copyright information

© Association of Clinical Biochemists of India 2010

Authors and Affiliations

  1. 1.Department of Biochemistry & JB Tropical Disease Research CentreMahatma Gandhi Institute of Medical SciencesSevagramIndia

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