Indian Journal of Clinical Biochemistry

, Volume 25, Issue 1, pp 77–81 | Cite as

Clinical correlation of alteration of endogenous antioxidant-uric acid level in major depressive disorder

  • Kiran ChaudhariEmail author
  • S. Khanzode
  • S. Khanzode
  • G. Dakhale
  • A. Saoji
  • S. Sarode
Original Article


Derangement of antioxidant levels in major depressive disorder had been correlated with oxidative damage. The effect of Selective Serotonin Re-Uptake Inhibitors on endogenous antioxidant uric acid levels in major depressive disorder has never been examined. This was a prospective; open labeled, parallel, 12 weeks study, in which serum uric acid levels and Hamilton Rating Scale for Depression score were estimated in age and sex matched thirty-six healthy and forty major depressive disorder subjects before and after fluoxetine and citalopram treatment. Significant decrease in serum uric acid (P<0.0001) was observed in newly diagnosed major depressive disorder subjects when compared to healthy subjects. The trend was reversed after 6 weeks more significantly after 12 weeks of treatment with improvement in Hamilton Rating Scale for Depression score. Also, Significant and negative correlation was found between Hamilton Rating Scale for Depression score and serum uric acid level (r= −0.864, P<0.001) after 12 weeks of treatment. Treatment with fluoxetine or citalopram reverses endogenous antioxidants like uric acid and improves Hamilton Rating Scale for Depression score in major depressive disorder.

Key Words

Uric acid Citalopram Fluoxetine Hamilton Rating Scale for Depression score Major depression Selective Serotonin Re-Uptake Inhibitors 


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Copyright information

© Association of Clinical Biochemists of India 2010

Authors and Affiliations

  • Kiran Chaudhari
    • 1
    • 6
    Email author
  • S. Khanzode
    • 2
  • S. Khanzode
    • 1
  • G. Dakhale
    • 5
  • A. Saoji
    • 3
  • S. Sarode
    • 4
  1. 1.Department of PharmacologyGovernment Medical College NagpurMaharashtraIndia
  2. 2.Department of MedicineGovernment Medical College NagpurMaharashtraIndia
  3. 3.Department of PsychiatryGovernment Medical College NagpurMaharashtraIndia
  4. 4.Department of PhysiologyGovernment Medical College NagpurMaharashtraIndia
  5. 5.Department of PharmacologyIndira Gandhi Government Medical CollegeNagpurIndia
  6. 6.Plot No: 66Saraswati SocietyDeendayal Nagar, NagpurIndia

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