Indian Journal of Clinical Biochemistry

, Volume 24, Issue 1, pp 98–101

Oxidative stress in Parkinson’s disease

  • Shashikant Nikam
  • Padmaja Nikam
  • S. K. Ahaley
  • Ajit V. Sontakke


Oxidative stress contributes to the cascade, leading to dopamine cell degeneration in Parkinson’s disease. However, oxidative stress is intimately linked to other components of the degenerative process, such as mitochondrial dysfunction, excitotoxicity, nitric oxide toxicity and inflammation. It is therefore difficult to determine whether oxidative stress leads to or is a consequence of, these events. Oxidative stress was assessed by estimating lipid peroxidation product in the form of thiobarbituric acid reactive substances, nitric oxide in the form of nitrite & nitrate. Enzymatic antioxidants in the form of superoxide dismutase, glutathione peroxidase, catalase, ceruloplasmin and non enzymatic antioxidant vitamins e.g. vitamin E and C in either serum or plasma or erythrocyte in 40 patients of Parkinson’s disease in the age group 40–80 years. Trace elements e.g. copper, zinc and selenium were also estimated. Plasma thiobarbituric acid reactive substances and nitric oxide levels were Significantly high but superoxide dismutase, glutathione peroxidase, catalase, ceruloplasmin, vitamin-E, vitamin-C, copper, zinc and selenium levels were significantly low in Parkinson’s disease when compared with control subjects. Present study showed that elevated oxidative stress may be playing a role in dopaminergic neuronal loss in substentia nigra pars compacta and involved in pathogenesis of the Parkinson’s disease.

Key Words

Oxidative stress Antioxidants Pathogenesis Parkinson’s disease 


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Copyright information

© Association of Clinical Biochemists of India 2009

Authors and Affiliations

  • Shashikant Nikam
    • 1
    • 3
  • Padmaja Nikam
    • 1
  • S. K. Ahaley
    • 1
  • Ajit V. Sontakke
    • 2
  1. 1.Department of BiochemistryGovernment Medical CollegeMirajIndia
  2. 2.KIMSKaradIndia
  3. 3.Department of BiochemistryBelgaum Institute of Medical SciencesBelgaumIndia

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