Correlation between Apgar score and urinary uric acid to creatinine ratio in perinatal asphyxia
- First Online:
- 47 Downloads
A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was found that the ratios were significantly higher in cases than controls (3.1± 1.3 vs 0.96± 0.54; P < 0.001) and among asphyxia patients, a significant negative linear correlation was found between the uric acid to creatinine ratio and the Apgar score (r = −0.857, P < 0.001). So urinary uric acid to creatinine ratio can be used as an additional non-invasive dispace, easy and at the same time early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and severity grading of asphyxia by Apgar score.
Key WordsPerinatal Asphyxia Apgar score Urinary uric acid to creatinine ratio
Unable to display preview. Download preview PDF.
- 1.Snyder EY, Cloherty JP. Perinatal Asphyxia. In: Cloherty JP, Stark Ann R, editors. Manual of Neonatal Care, 4ed. Philadelphia: Lippincott-Raven Publishers, 1998: p 530.Google Scholar
- 4.Newman DJ, Price CP. Nonprotein Nitrogen Metabolites. In: Burtis CA, Ashwood ER, editors. Tietz Fundamentals of Clinical Chemistry, 5 ed. Philadelphia: Saunders, 2001: p 422.Google Scholar
- 5.Newman DJ, Price CP. Nonprotein Nitrogen Metabolites. In: Burtis CA, Ashwood ER, editors. Tietz Fundamentals of Clinical Chemistry. 5 ed. Philadelphia: Saunders. 2001: p 420.Google Scholar
- 6.Dutta DC, Konar H. Diseases of the Fetus and the Newborn. In: Dutta DC, Konar H, editors. Text Book of Obstetrics Including Perinatology and Contraception. 4 ed. Calcutta: New Central Book Publisher, 1998: 504–505.Google Scholar
- 11.Erdag GC, Vitrinel A. Can urinary uric acid/ creatinine ratio be used as an additional marker for neonatal asphyxia? International Pediatrics 2004; 19(4): 217–219.Google Scholar
- 12.Chen HJ, Yau KIT, Tsai KS. Urinary uric acid/ creatinine ratio as an additional marker of perinatal asphyxia. J Formos Med Assoc 2000; 99: 773–774.Google Scholar