Indian Journal of Clinical Biochemistry

, Volume 23, Issue 4, pp 361–364

Correlation between Apgar score and urinary uric acid to creatinine ratio in perinatal asphyxia

  • Pallab Basu
  • Sabyasachi Som
  • Nabendu Choudhuri
  • Harendranath Das
Article

Abstract

A randomized case control hospital based study was conducted over 12 months time on 31 asphyxiated and 31 normal newborn to see whether urinary uric acid can be used as a marker of perinatal asphyxia and can be correlated with the clinical diagnosis by Apgar score. Uric acid and creatinine were estimated in spot urine within 24 hours after birth in both cases and controls. A ratio between concentrations of uric acid to creatinine was estimated and compared between cases and controls. It was found that the ratios were significantly higher in cases than controls (3.1± 1.3 vs 0.96± 0.54; P < 0.001) and among asphyxia patients, a significant negative linear correlation was found between the uric acid to creatinine ratio and the Apgar score (r = −0.857, P < 0.001). So urinary uric acid to creatinine ratio can be used as an additional non-invasive dispace, easy and at the same time early biochemical marker of birth asphyxia which biochemically supports the clinical diagnosis and severity grading of asphyxia by Apgar score.

Key Words

Perinatal Asphyxia Apgar score Urinary uric acid to creatinine ratio 

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Copyright information

© Association of Clinical Biochemists of India 2008

Authors and Affiliations

  • Pallab Basu
    • 1
  • Sabyasachi Som
    • 1
    • 2
  • Nabendu Choudhuri
    • 1
    • 2
  • Harendranath Das
    • 1
  1. 1.Department of BiochemistryBurdwan Medical College and HospitalBurdwanIndia
  2. 2.Department of PediatricsBurdwan Medical College and HospitalBurdwanIndia
  3. 3.Department of BiochemistryBurdwan Medical College & HospitalBurdwanIndia

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