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Indian Journal of Clinical Biochemistry

, Volume 23, Issue 4, pp 341–344 | Cite as

Effects of chronic ethanol exposure on renal function tests and oxidative stress in kidney

  • Subir Kumar DasEmail author
  • Sowmya Varadhan
  • L. Dhanya
  • Sukhes Mukherjee
  • D. M. Vasudevan
Article

Abstract

After administration, ethanol and its metabolites go through the kidneys and are excreted into urine. The kidney seems to be the only vital organ generally spared in chronic alcoholics. Therefore, we investigated the multiple effects of chronic ethanol exposure on renal function tests and on oxidative stress related parameters in the kidney. Chronic ethanol (1.6 g ethanol/ kg body weight/ day) exposure did not show any significant change in relative weight (g/ 100g body weight) of kidneys, serum calcium level or glutathione s-transferase activity. However, urea and creatinine concentration in serum, and TBARS level in kidney elevated significantly, while reduced glutathione content and activities of glutathione peroxidase, glutathione reductase and superoxide dismutase diminished significantly after 12 weeks of ethanol exposure. Catalase activity showed increased activity after 4 weeks of ethanol exposure and decreased activity after 12 weeks of ethanol exposure. Genesis of renal ultrastructural abnormalities after 12 weeks of ethanol exposure may be important for the development of functional disturbances. This study revealed that chronic ethanol exposure for longer duration is associated with deleterious effects in the kidney.

Key Words

Ethanol Glutathione Kidney Oxidative stress Renal function 

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Copyright information

© Association of Clinical Biochemists of India 2008

Authors and Affiliations

  • Subir Kumar Das
    • 1
    Email author
  • Sowmya Varadhan
    • 1
  • L. Dhanya
    • 1
  • Sukhes Mukherjee
    • 1
  • D. M. Vasudevan
    • 1
  1. 1.Department of BiochemistryAmrita Institute of Medical SciencesElamakkaraIndia

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