Diagnostic strategies for subclinical hypothyroidism

  • Shruti MohantyEmail author
  • W. Amruthlal
  • G. C. Reddy
  • G. Kusumanjali
  • A. S. Kanagasabapathy
  • Pragna Rao


The aim of this study is to delineate laboratory diagnostic strategies for subclinical hypothyroidism in patients who are clinically symptomatic but may have a normal thyroid profile. Tri — iodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) and anti thyroid peroxidase antibodies (anti-TPO) were estimated on fasting blood samples from 99 patients using electrochemiluminescence methods on ELECSYS 1010 (Roche). 74% of study subjects had elevated anti-TPO levels.61% patients had subclinical hypothyroidism. 45 of the 61 subclinical hypothyroid patients had elevated anti-TPO levels (73%). This is an important finding suggesting an autoimmune etiology for subclinical thyroid dysfunction with a higher risk of developing overt hypothyroidism.

Key words

Hypothyroidism Thyroid Profile T3 T4 TSH Anti TPO 


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Copyright information

© Association of Clinical Biochemists of India 2008

Authors and Affiliations

  • Shruti Mohanty
    • 1
    Email author
  • W. Amruthlal
    • 1
    • 2
  • G. C. Reddy
    • 1
  • G. Kusumanjali
    • 1
  • A. S. Kanagasabapathy
    • 1
  • Pragna Rao
    • 1
  1. 1.Department of BiochemistryKamineni Institute of Medical SciencesNarkatpallyIndia
  2. 2.Department of ENTKamineni Institute of Medical SciencesNarkatpallyIndia

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