Rifampin Induced Thrombotic Thrombocytopenic Purpura

  • Hannah Hamad
  • Kamal Kant SahuEmail author
  • Steven Dunn
  • Lucia Milla
  • Alice Caffery
  • Nahida Islam

To the Editor,

Thrombotic thrombocytopenic purpura (TTP) is one of the rare but fatal entity. The close differentials like hemolytic uremic syndrome (HUS) and atypical hemolytic uremic syndrome (atypical HUS) needs to be promptly ruled out as the management differs with the diagnosis. Rifampin induced TTP is limited to few case reports. This rare association should always be considered in any case who presents with anemia and thrombocytopenia.

A 55-year-old female presented for the complaints of malaise, headache, anorexia, and nausea of one-week duration. She denied fever, chills, cough, expectoration, abdominal pain and diarrhea. Three weeks ago, she was started on rifampin 150 mg once daily for latent tuberculosis. To note that earlier, she developed isoniazid (INH) induced hepatotoxicity following which INH was stopped and rifampin was started.

On examination, her vitals were stable and was alert and oriented to time, place and person. No pallor, jaundice, petechial spots,...


Author Contribution

All authors have seen the manuscript and agree to the content and data. All the authors played a significant role in the paper.



Compliance with Ethical Standards

Conflict of interest

Authors have no conflicts of interest to declare.

Ethical Statement

The article doesn’t contain participation of any human being and animal.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2020

Authors and Affiliations

  1. 1.University of Massachusetts Medical SchoolWorcesterUSA
  2. 2.Saint Vincent HospitalWorcesterUSA
  3. 3.Hemato-Oncology DivisionUniversity of Massachusetts Medical SchoolWorcesterUSA

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