Plasmablastic Lymphoma Versus EBV-Positive Myeloma
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EBV-Positive Myeloma Versus Plasmablastic Lymphoma
Hematolymphoid neoplasms with plasmablastic lymphoma (PBL) and plamablastic/anaplastic myeloma (PBM) show significant morphological and/or immunophenotypic overlap which may make it very difficult for pathologists to make a definite and specific histopathological diagnosis . Features such as renal dysfunction, significant paraprotein, osteolytic bony lesions, hypercalcemia and diffuse bone marrow involvement favor a diagnosis of PBM. In contrast, EBER expression in neoplastic cells, HIV coinfection and high proliferative index support a diagnosis of PBL. When myeloma-defining signs are incomplete or absent, the presence of oropharyngeal soft tissue lesion or lymphadenopathy favor a diagnosis of PBL, regardless of bone marrow disease. The distinction is very important as the treatment of these entities differ remarkably. PBL is an aggressive disease with relapsing clinical course and has higher rates of disease progression and...
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The authors state that there is no conflict of interest present.
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.