Advertisement

Plasmablastic Lymphoma Versus EBV-Positive Myeloma

  • Divya Bansal
  • Neha SinghEmail author
  • Narendra Agrawal
  • Anurag Mehta
Correspondence
  • 2 Downloads

EBV-Positive Myeloma Versus Plasmablastic Lymphoma

Hematolymphoid neoplasms with plasmablastic lymphoma (PBL) and plamablastic/anaplastic myeloma (PBM) show significant morphological and/or immunophenotypic overlap which may make it very difficult for pathologists to make a definite and specific histopathological diagnosis [1]. Features such as renal dysfunction, significant paraprotein, osteolytic bony lesions, hypercalcemia and diffuse bone marrow involvement favor a diagnosis of PBM. In contrast, EBER expression in neoplastic cells, HIV coinfection and high proliferative index support a diagnosis of PBL. When myeloma-defining signs are incomplete or absent, the presence of oropharyngeal soft tissue lesion or lymphadenopathy favor a diagnosis of PBL, regardless of bone marrow disease. The distinction is very important as the treatment of these entities differ remarkably. PBL is an aggressive disease with relapsing clinical course and has higher rates of disease progression and...

Notes

Compliance with Ethical Standards

Conflict of interest

The authors state that there is no conflict of interest present.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

References

  1. 1.
    Harmon CM, Smith LB (2016) Plasmablastic lymphoma a review of clinicopathologic features and differential diagnosis. Arch Pathol Lab Med 140:1074–1078CrossRefPubMedGoogle Scholar
  2. 2.
    Ahn JS, Okal R, Vos JA et al (2017) Plasmablastic lymphoma versus plasmablastic myeloma: an ongoing diagnostic dilemma. J Clin Pathol 70(9):775–780CrossRefPubMedGoogle Scholar
  3. 3.
    Castillo JJ, Bibas M, Miranda RN (2015) The biology and treatment of plasmablastic lymphoma. Blood 125:2323–2330CrossRefPubMedGoogle Scholar
  4. 4.
    Chang ST, Liao YL, Lu CL et al (2007) Plasmablastic cytomorphologic features in plasma cell neoplasms in immunocompetent patients are significantly associated with EBV. Am J Clin Pathol 128:339–344CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2019

Authors and Affiliations

  1. 1.Department of Pathology and Lab ServicesRajiv Gandhi Cancer Institute and Research CenterRohiniIndia
  2. 2.Department of Hemato-OncologyRajiv Gandhi Cancer Institute and Research CenterRohiniIndia

Personalised recommendations