The Metabolic Profiles in Hematological Malignancies
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Leukemia is one of the most aggressive hematological malignancies. Leukemia stem cells account for the poor prognosis and relapse of the disease. Decades of investigations have been performed to figure out how to eradicate the leukemia stem cells. It has also been known that cancer cells especially solid cancer cells use energy differently than most of the cell types. The same thing happens to leukemia. Since there are metabolic differences between the hematopoietic stem cells and their immediate descendants, we aim at manipulating the energy sources with which that could have an effect on leukemia stem cells while sparing the normal blood cells. In this review we summarize the metabolic characteristics of distinct leukemias such as acute myeloid leukemia, chronic myeloid leukemia, T cell lymphoblastic leukemia, B-cell lymphoblastic leukemia, chronic lymphocytic leukemia and other leukemia associated hematological malignancies such as multiple myeloma and myelodysplastic syndrome. A better understanding of the metabolic profiles in distinct leukemias might provide novel perspectives and shed light on novel metabolic targeting strategies towards the clinical treatment of leukemias.
KeywordsHematological malignancies Leukemia stem cells Metabolism
Acute myeloid leukemia
Chronic myeloid leukemia
T-cell lymphoblastic leukemia
B-cell lymphoblastic leukemia
Chronic lymphocytic leukemia
Leukemia stem cells
Fatty acid oxidation
Pentose phosphate pathway
Glucose transporter 1
Receptor tyrosine kinases
Reactive oxygen species
Cancer stem cells
Proliferator-activated receptor gamma ligands
Carnitine O-palmitoyltransferase I
Gonadal adipose tissue
Isocitrate dehydrogenase 1 and 2
Polycomb repressive complex 2
This study was supported by grants from Project of Shanghai Municipal Health Bureau (Surface Program, SHXH201402).
All authors read and approved the final manuscript. BL designed the manuscript and TL and XP wrote the review.
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Conflict of interest
The authors declare that they have no conflict of interest.
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All authors are compliant with ethical standards.
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All authors approve the manuscript for publication.
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Data and materials related to this work are available upon request.
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