Study of Haploidentical Stem Cell Transplantation for Philadelphia/BCR-ABL Positive Acute Lymphoblstic Leukemia
Philadelphia chromosomal (Ph+) abnormality is seen in 25% of adult and 3–5% of pediatric acute lymphoblastic leukemia (ALL) patients and is associated with high relapse rates . Consolidation with HLA matched or Haplo-idential Allogeneic Stem Cell Transplantation (HaSCT) has been associated with better outcome in adult Ph + ALL patients [2, 3].
We are presenting our experience of HaSCT (HLAs matched at 5–8/10 of sibling or parents) for Ph + ALL patients from January-2012 to December-2017. Patients were followed up till 30-September-2018.
Out of 58 Ph + ALL patients during study period 10 patients (males = 6, median age 27.5 years, 17–42 years) received HaSCT after achieving first or second complete remission following intensive chemotherapy and tyrosine kinase inhibitor (Imatinib = 1, Dasatinib = 9). Six patients had Philadelphia chromosome while all patients had BCR-ABL detected by PCR. At the time of HaSCT, 5 patients were in CR1 and remaining in CR2. Eight patients...
We would like to acknowledge to Ms. Jyotsna Kapoor for statistical inputs and entire team of hemato-oncology and bone marrow transplant unit, Rajiv Gandhi Cancer Institute & Research Centre for their continuous support for retrieving records of eligible patients.
Compliance with Ethical Standards
Conflict of interest
Narendra Agrawal, Neha Yadav, Priyanka Verma, Priyanka Soni, Pallavi Mehta, Shinto Francis Thekkudan, Rayaz Ahmed, Dinesh Bhurani declare that they have no conflict of interest.
- 1.Jain K, Arlin Z, Mertelsmann R, Gee T, Kempin S, Koziner B, Middleton A, Jhanwar S, Chaganti R, Clarkson B (1983) Philadelphia chromosome and terminal transferase—positive acute leukemia: similarity of terminal phase of chronic myelogenous leukemia and de novo acute presentation. J Clin Oncol 1:669CrossRefGoogle Scholar
- 2.Chen H, Liu KY, Xu LP, Liu DH, Chen YH, Zhao XY et al (2012) Administration of imatinib after allogeneic hematopoietic stem cell transplantation may improve disease-free survival for patients with Philadelphia chromosome-positive acute lymphoblastic leukemia. J Hematol Oncol 5:29. https://doi.org/10.1186/1756-8722-5-29 CrossRefGoogle Scholar
- 3.Gao L, Zhang C, Gao L, Liu Y, Yi S, Wang S, Li B, Yang T, Yuan Z, Zhang X (2015) Favorable outcome of haploidentical hematopoietic stem cell transplantation in Philadelphia chromosome-positive acute lymphoblastic leukemia: a multicenter study in Southwest China. J Hematol Oncol 8:90. https://doi.org/10.1186/s13045-015-0186-5 CrossRefGoogle Scholar
- 4.Santoro N, Ruggeri A, Labopin M et al (2017) Unmanipulated haploidentical stem cell transplantation in adults with acute lymphoblastic leukemia: a study on behalf of the Acute Leukemia Working Party of the EBMT. J Hematol Oncol 10(1):113. https://doi.org/10.1186/s13045-017-0480-5 CrossRefGoogle Scholar