A Case Report of a Rare Rh Phenotype: D—
Rh blood group (ISBT: 004) is the second major blood grouping system in addition to ABO, which was first described 60 years ago [1, 2]. Rh factor is an inherited blood protein or antigen on red blood cells . This system includes at least 45 independent antigens from which D, C, c, E, and e are more important for transfusion medicine . Among Rh antigens, e is the most common antigen (98.3%), followed by D (94.2%), C (88.11%), c (54.5%), and E (18.6%) . Rh blood group antigens are highly complicated because of polymorphism in genes encoding them . D and CE proteins/antigens in the Rh blood group system are encoded by RHD and RHCE genes stretching along a 75 kb sequence located on chromosome 1p36.11. Each Rh gene consists of 10 exons that are highly homologous with 93.8% amino acid identity, and RHAG protein on RBC surface is necessary for the expression of Rh antigens. Because of high immunogenicity, D antigen has been recognized as the most important Rh antigen...
We are grateful to the Iranian Blood Transfusion Organization for their invaluable scientific support.
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All authors have agreed the journals policy and authorship agreement. All authors explicitly declare no conflict of interest. Furthermore, informed consent was obtained from all individual participants included in the study.
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