A Case Report of a Rare Rh Phenotype: D—

  • Maryam Samareh Salavati Pour
  • Saeed Soleimany
  • Narges Ghasemimehr
  • Roohollah Mirzaee KhalilabadiEmail author


Rh blood group (ISBT: 004) is the second major blood grouping system in addition to ABO, which was first described 60 years ago [1, 2]. Rh factor is an inherited blood protein or antigen on red blood cells [2]. This system includes at least 45 independent antigens from which D, C, c, E, and e are more important for transfusion medicine [3]. Among Rh antigens, e is the most common antigen (98.3%), followed by D (94.2%), C (88.11%), c (54.5%), and E (18.6%) [4]. Rh blood group antigens are highly complicated because of polymorphism in genes encoding them [5]. D and CE proteins/antigens in the Rh blood group system are encoded by RHD and RHCE genes stretching along a 75 kb sequence located on chromosome 1p36.11. Each Rh gene consists of 10 exons that are highly homologous with 93.8% amino acid identity, and RHAG protein on RBC surface is necessary for the expression of Rh antigens. Because of high immunogenicity, D antigen has been recognized as the most important Rh antigen...



We are grateful to the Iranian Blood Transfusion Organization for their invaluable scientific support.

Compliance with Ethical Standards

Conflict of interest

All authors have agreed the journals policy and authorship agreement. All authors explicitly declare no conflict of interest. Furthermore, informed consent was obtained from all individual participants included in the study.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2019

Authors and Affiliations

  1. 1.Student Research CommitteeKerman University of Medical SciencesKermanIran
  2. 2.Cell Therapy and Regenerative Medicine Comprehensive CenterKerman University of Medical SciencesKermanIran
  3. 3.Department of Hematology and Laboratory Sciences, Faculty of Allied MedicineKerman University of Medical SciencesKermanIran
  4. 4.Blood Transfusion Research CenterHigh Institute for Research and Education in Transfusion MedicineTehranIran

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