Rare Presentations of Acute Lymphoblastic Leukemia

  • Kamal Kant SahuEmail author
  • Susan V. George
  • Ahmad Daniyal Siddiqui

Dear Editor,

Mishra et al. [1] recently reported a rare dermatological presentation of acute lymphoblastic leukemia (ALL). With regards to rare presentations, we hereby present a short review on unusual manifestations and dermatological presentations of ALL.

Fever, shortness of breath, lethargy and night sweats are the common presenting symptoms of ALL. Recently, there have been reports on rare and unusual presentations of ALL like calf pain, retinal detachment, nephromegaly etc. Recently, researchers have also shown interest in studying the dermatological manifestations in association with leukemia [2, 3, 4, 5, 6, 7]. Maheshwari et al. [2] retrospectively reviewed their 12-year institutional data of 317 relapsed ALL patients and reported nine unusual presentations. Similarly, Shakibazad et al. [3] did a systematic literature review of 41 published studies on unusual presentations of ALL in children. They found musculoskeletal symptoms (34.2%) as the most common unusual initial...


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Conflict of interest

Authors have no conflicts of interest to declare.

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The article doesn’t contain participation of any human being and animal.


  1. 1.
    Mishra K, Jandial A, Sandal R, Lad D, Prakash G, Khadwal A et al (2018) Haemorrhagic bulla: a rare presentation of acute lymphoblastic leukemia. Indian J Hematol Blood Transfus. 1:1. Google Scholar
  2. 2.
    Maheshwari G (2018) Unusual presentations of acute lymphoblastic leukemia in children: a study of 9 patients. J Glob Oncol 4(Supplement 2):87sCrossRefGoogle Scholar
  3. 3.
    Shakibazad N, Haghpanah S, Shahriari M (2016) International conference on leukemia and hematologic oncology. J Hematol Thrombo Dis 4(Suppl 5):37Google Scholar
  4. 4.
    Millot F, Robert A, Bertrand Y, Mechinaud F, Laureys G, Ferster A et al (1997) Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. The Children’s Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC). Pediatrics 100(1):60–64CrossRefGoogle Scholar
  5. 5.
    Pulido-Díaz N, Medina G, Palomino N, Peralta F (2015) Cutaneous manifestations of leukemia. Rev Med Inst Mex Seguro Soc 53(Suppl 1):S30–S35Google Scholar
  6. 6.
    Aggarwal S, Malhotra P, Dogra S, Vinay K, Kanwar AJ, Saikia UN (2016) Spectrum of mucocutaneous manifestations in an Asian cohort of patients with leukemia. Int J Dermatol 55(8):893–897CrossRefGoogle Scholar
  7. 7.
    Aggarwal S, Malhotra P, Dogra S, Vinay K, Kanwar AJ, Saikia UN (2016) Therapy-related cutaneous adverse effects in an Indian cohort of adult leukaemia patients. J Eur Acad Dermatol Venereol 30(12):e202–e204CrossRefGoogle Scholar
  8. 8.
    Sahu KK, Mishra A, Chastain I (2018) Novel anticancers and dermatological adversities: old rivals but new challenges. BMJ Case Rep 14:11Google Scholar
  9. 9.
    Mishra AK, Sahu KK, Atem J (2019) Disseminated herpes zoster following treatment with benralizumab. Clin Respir JGoogle Scholar

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© Indian Society of Hematology and Blood Transfusion 2019

Authors and Affiliations

  1. 1.Department of MedicineSaint Vincent HospitalWorcesterUSA
  2. 2.Division of Hematology and Medical OncologySaint Vincent Cancer and Wellness CenterWorcesterUSA

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