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Leukemia Cutis: A Rare Initial Presentation of Chronic Lymphocytic Leukemia

  • Abhenil Mittal
  • Ajay Gogia
  • Saumyaranjan Mallick
  • Ritu Gupta
Correspondence

Dear Editor,

CLL is the most common adult leukemia in western countries accounting for 25–30% cases with a median age of diagnosis of 70 years [1]. Most patients are asymptomatic at diagnosis and come to clinical attention due to incidentally detected lymphocytosis. Cutaneous lesions can be seen in 25% of CLL cases but usually represent non-specific etiology like infection, autoimmune phenomenon or even more common in relapse/refractory cases [2]. True leukemic involvement is seen in less than 5% cases and may portend a better prognosis. Here, we describe a case of CLL with skin involvement at initial presentation.

A 45-year-old lady, with no prior co-morbidities was referred to our center with complaints of swelling over the left earlobe and the bridge of nose for 6 months. On examination, she had generalized lymphadenopathy with multiple palpable cervical, axillary and inguinal lymph nodes. Her baseline compete blood count showed a total leucocyte count of 125,000 with 90% abnormal...

References

  1. 1.
    Siegel RL, Miller KD, Jemal A (2018) Cancer statistics, 2018. CA Cancer J Clin 68:7–30CrossRefPubMedPubMedCentralGoogle Scholar
  2. 2.
    Robak E, Robak T (2007) Skin lesions in chronic lymphocytic leukemia. Leuk Lymphoma 485:855–865CrossRefGoogle Scholar
  3. 3.
    Giles FJ, O’Brien SM, Keating MJ (1998) Chronic lymphocytic leukemia in (Richter’s) transformation. Semin Oncol 25:117–125PubMedPubMedCentralGoogle Scholar
  4. 4.
    Cerroni L, Zenahlik P, Hofler G (1996) Specific cutaneous infiltrates of B-cell chronic lymphocytic leukemia: a clinicopathologic and prognostic study of 42 patients. Am J Surg Pathol 20:1000–1010CrossRefPubMedPubMedCentralGoogle Scholar
  5. 5.
    Colburn DE, Welch MA, Giles FJ (2002) Skin infiltration with chronic lymphocytic leukemia is consistent with a good prognosis. Hematology 7:187–188CrossRefPubMedGoogle Scholar

Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  • Abhenil Mittal
    • 1
  • Ajay Gogia
    • 1
  • Saumyaranjan Mallick
    • 2
  • Ritu Gupta
    • 3
  1. 1.Department of Medical Oncology, DRBRAIRCHAIIMSNew DelhiIndia
  2. 2.Department of PathologyAIIMSNew DelhiIndia
  3. 3.Department of Laboratory OncologyAIIMSNew DelhiIndia

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