Chromosome 12 Rearrangement in an Adolescent with Primary Myelofibrosis

  • Moeinadin SafaviEmail author
  • Atoosa Gharib
  • Mohammad Taghi Haghi Ashtiani
  • Poorya Salajegheh
  • Mohammad VaseiEmail author

Dear Editor,

Primary myelofibrosis (PMF) is a Philadelphia negative myeloproliferative neoplasm with bone marrow megakaryocytic and granulocytic proliferation along with fibrosis and extramedullary hematopoiesis. There is a sequential evolution in PMF from a prefibrotic to a fibrotic stage [1].

The patient was a 14 year-old-girl with thrombocytemia and the following complete blood count: white blood cell = 8000/µL, hemoglobin = 10.2 g/dl and platelet = 1,200,000/µL and treatment with anagrilide was started for her. Two year later, she complained of fatigue and abdominal fullness. Imaging workup revealed an enlarged spleen in sonography measuring 166 × 70 mm. Complete blood count showed leukocytosis, anemia and thrombocytopenia with a leucoerythroblastic change in peripheral blood smear (white blood cell = 15,800/µL, hemoglobin = 9 g/dl, platelet = 110,000/µL). Subsequently, she underwent bone marrow biopsy which showed grade 2 reticulin fibrosis along with megakaryocytic and...


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Conflict of interest

Authors declares that he/she has no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from individual participant included in the study.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  • Moeinadin Safavi
    • 1
    Email author
  • Atoosa Gharib
    • 1
    • 2
  • Mohammad Taghi Haghi Ashtiani
    • 1
  • Poorya Salajegheh
    • 3
  • Mohammad Vasei
    • 1
    Email author
  1. 1.Molecular Pathology and Cytogenetics Section, Pathology Department, Children’S Medical CenterTehran University of Medical SciencesTehranIran
  2. 2.Pathology Department, Shahid Modarres HospitalShahid Beheshti University of Medical SciencesTehranIran
  3. 3.Pediatric Hematology-Oncology Ward, Afzalipoor HospitalKerman University of Medical SciencesKermanIran

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